장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재)
특정 표적장기 독성 - 1회 노출
구분 1
위험
P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210
열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P311
의료기관(의사)의 진찰을 받으시오.
SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE C화학적 특성, 용도, 생산
개요
Sibutramine was introduced as Meridia in the US for the control of
obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared
in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and
noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by
creating a satieted feeling and increases energy expenditure by enhancing
thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of
Sibutramine once-daily, meaningful weight loss was sustained for 12 months ;
an additional study demonstrated a lack of abuse potential. An appreciable part
of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites,
which are very potent monoamine reuptake inhibitors
themselves.
화학적 성질
White Solid
용도
A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure