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유당

유당
유당 구조식 이미지
카스 번호:
63-42-3
한글명:
유당
동의어(한글):
락토오스;유당;락토오스(LACTOSE)
상품명:
Lactose
동의어(영문):
LACTIN;LACTOSE;Lactosum;D-LACTOSE;Galactinum;Aletobiose;Osmolactan;LACTOBIOSE;SUGAR MILK;MILK SUGAR
CBNumber:
CB8710411
분자식:
C12H22O11
포뮬러 무게:
342.3
MOL 파일:
63-42-3.mol

유당 속성

녹는점
222.8°C
끓는 점
397.76°C (rough estimate)
밀도
1.5300
굴절률
1.5376 (estimate)
저장 조건
2-8°C
용해도
Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent).
물리적 상태
Powder
산도 계수 (pKa)
12.39±0.20(Predicted)
색상
White to Off-white
수용성
5-10 g/100 mL at 20 ºC
BRN
93796
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
63-42-3(CAS DataBase Reference)
NIST
D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3)
EPA
Lactose (63-42-3)

안전

안전지침서 24/25
WGK 독일 2
RTECS 번호 OD9625000
TSCA Yes
HS 번호 17021100
유해 물질 데이터 63-42-3(Hazardous Substances Data)
기존화학 물질 KE-17416

유당 C화학적 특성, 용도, 생산

개요

젖당은 이름 그대로 포유류의 젖, 특히 초유 속에서 많이 발견되며, 그 양은 모유에 6.7%, 우 유에 4.5% 정도 함유되어 있다. 모유 속에서는 이 밖에도 10종 이상의 소당류가 발견되는데, 이들 은 모두 락토오스를 골격구조로 가지고 있다. 젖당은 젖 이 외에서는 별로 발견되지 않았으나, 식물 의 씨에서 발견되었다는 몇 가지 보고가 있다.

용도

유아영양,의약의희석제.

화학적 성질

white crystals or powder

화학적 성질

Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose.

용도

A disaccharide sugar present in milk.

용도

Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent.

용도

D-Lactose is used for the culture of lactic acid metabolizing bacteria, lactic acid bacteria. D-Lactose is used to identify and characterized galectins.

정의

A sugar found in milk. It is a disaccharide composed of glucose and galactose units.

생산 방법

There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available.

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

공기와 물의 반응

Water soluble.

반응 프로필

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

건강위험

ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic.

Pharmaceutical Applications

Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections.

Safety

Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms.

저장

Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day.
Lactose anhydrous should be stored in a well-closed container in a cool, dry place.

Purification Methods

-Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.]

비 호환성

Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation.
Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups.
Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

유당 준비 용품 및 원자재

원자재

준비 용품


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