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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 구조식 이미지
카스 번호:
62252-26-0
상품명:
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
동의어(영문):
JLK6;JCP 251);JCP251 (JCP-251;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one
CBNumber:
CB8741619
분자식:
C10H8ClNO3
포뮬러 무게:
225.63
MOL 파일:
62252-26-0.mol

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 속성

녹는점
115 °C
끓는 점
456.1±45.0 °C(Predicted)
밀도
1.46±0.1 g/cm3(Predicted)
저장 조건
Store at RT
산도 계수 (pKa)
1.95±0.20(Predicted)

안전

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN C화학적 특성, 용도, 생산

생물학적 활성

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 준비 용품 및 원자재

원자재

준비 용품


7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 공급 업체

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