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로퍼라미드 하이드로클로라이드

로퍼라미드 하이드로클로라이드
로퍼라미드 하이드로클로라이드 구조식 이미지
카스 번호:
34552-83-5
한글명:
로퍼라미드 하이드로클로라이드
동의어(한글):
로퍼라미드하이드로클로라이드;로퍼라미드하이드로클로라이드(LOPERAMIDEHYDROCHLORIDE)
상품명:
Loperamide hydrochloride
동의어(영문):
blox;pj185;imosec;Imosse;r18553;Clalet;imodium;Imossel;lopemid;lopemin
CBNumber:
CB8758181
분자식:
C29H34Cl2N2O2
포뮬러 무게:
513.5
MOL 파일:
34552-83-5.mol

로퍼라미드 하이드로클로라이드 속성

녹는점
223-225°C
밀도
1.1905 (rough estimate)
굴절률
1.6100 (estimate)
저장 조건
2-8°C
용해도
Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
산도 계수 (pKa)
8.66(at 25℃)
물리적 상태
neat
Merck
14,5571
CAS 데이터베이스
34552-83-5(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 25
안전지침서 45
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 TM4960000
위험 등급 6.1(b)
포장분류 III
HS 번호 29333990
독성 LD50 in mice (mg/kg): 75 s.c.; 28 i.p.; 105 orally; in rats (mg/kg): 185 orally (Niemegeers)
기존화학 물질 KE-05835
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P321 (…) 처치를 하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405 밀봉하여 저장하시오.

로퍼라미드 하이드로클로라이드 C화학적 특성, 용도, 생산

화학적 성질

White Solid

용도

Loperamide hydrochloride is a Ca2+ channel protein inhibitor and MOR activator.

Indications

Loperamide hydrochloride (Imodium) structurally resembles both haloperidol and meperidine. In equal doses, loperamide protects against diarrhea longer than does diphenoxylate. It reduces the daily fecal volume and decreases intestinal fluid and electrolyte loss. Loperamide produces rapid and sustained inhibition of the peristaltic reflex through depression of longitudinal and circular muscle activity.The drug also possesses antisecretory activity, presumably through an effect on intestinal opioid receptors.

정의

ChEBI: A hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

일반 설명

Loperamide is an antidiarrheal agent used in controlling acute nonspecific diarrhea and chronic diarrhea associated with inflammatory bowel diseases.

생물학적 활성

High affinity μ -opioid receptor agonist with peripheral selectivity (K i values are 2, 48 and 1156 nM for μ -, δ - and κ -opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca 2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca 2+ channels and at higher concentrations it reduces Ca 2+ flux through NMDA receptor operated channels.

Mechanism of action

Loperamide also is a potent inhibitor of intestinal CYP3A4, increasing the intestinal absorption of other CYP3A4 substrates. The clinically significant drug interactions of loperamide with coadministered CYP3A4 and CYP2C8 substrates or inhibitors would be limited, however, because of its two metabolic pathways.

Pharmacokinetics

Loperamide is marketed as capsules (2 mg) and liquid (1 mg/5 mL) preparations. The recommended dose is 4 mg initially and an additional 2 mg following each diarrheal stool. The dose should not exceed 16 mg/day. It is too lipophilic to dissolve in water for an intravenous dosage form, a property that limits its abuse potential. The compound is highly lipophilic and undergoes slow dissolution, thus limiting the bioavailability of the agent to approximately 40% of the dose. Its low oral bioavailability also can be attributed to first-pass metabolism by both CYP2C8 and CYP3A4 to its primary N-demethyl metabolite. Peak plasma levels are reached in approximately 5 hours, with an elimination half-life of approximately 11 hours. Approximately 1% of the dose is excreted into the urine unchanged.

Clinical Use

Loperamide is effective against a wide range of secretory stimuli and can be used in the control and symptomatic relief of acute diarrhea that is not secondary to bacterial infection.

부작용

Adverse effects associated with its use include abdominal pain and distention, constipation, dry mouth, hypersensitivity, and nausea and vomiting.

로퍼라미드 하이드로클로라이드 준비 용품 및 원자재

원자재

준비 용품


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