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Vinorelbine tartrate

Vinorelbine tartrate 구조식 이미지
카스 번호:
125317-39-7
상품명:
Vinorelbine tartrate
동의어(영문):
NVB;KW-2307;Eunades;NAVELBINE;Pacilitaxel;VINORELBINE(RG);lbine Ditartrate;butanedioate(1:2);NAVELBINE TARTRATE;Vinorelbin artrate
CBNumber:
CB8761554
분자식:
C53H66N4O20
포뮬러 무게:
1079.11
MOL 파일:
125317-39-7.mol

Vinorelbine tartrate 속성

녹는점
181-183°C
저장 조건
2-8°C
용해도
H2O: 10 mg/mL
물리적 상태
powder
색상
off-white
InChIKey
PMDHUNWDGZSEMN-WTUOTUPFSA-N
CAS 데이터베이스
125317-39-7(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 43
안전지침서 26-36
유엔번호(UN No.) UN 1544PSN1 6.1 / PGII
WGK 독일 3
HS 번호 29339900
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 P264, P270, P301+P310, P321, P330,P405, P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.

Vinorelbine tartrate C화학적 특성, 용도, 생산

화학적 성질

Pale Yellow Powder

용도

An antineoplastic

정의

ChEBI: The L-(+)-tartrate salt of vinorelbine.

상표명

Navelbine (Pierre).

일반 설명

Vinorelbine ditartrate is available in 1- and 5-mL vials at aconcentration of 10 mg/mL for IV use. It is FDA approvedfor the treatment of NSCLC. The agent has also been usedin treating metastatic breast cancer, cervical cancer, uterinecancer, and lung cancer especially in older patients or thosewith physical difficulties. Vinorelbine is the most lipophilicof the vinca alkaloids because of modifications of thecatharanthine ring system and dehydration of the piperidinering. This allows the agent to be quickly taken up into cellsincluding lung tissue where concentrations are 300-foldhigher than plasma concentrations. This is 3 to 13 timeshigher than the lung concentrations seen with vincristine.The agent is highly protein bound (80%–91%) and metabolizedby CYP3A. The major metabolite seen is the 4-Odesacetylderivative, which is equally active with the parentbut only formed in small quantities. The agent is eliminatedprimarily (33%–88%) in the bile with some appearing inthe urine (16%–30%). The elimination half-life is 27 to43 hours. The toxicities seen for vinorelbine includemyelosuppression, which is dose limiting but ceases upondiscontinuation of drug. This is most commonly seen as aneutropenia, and patient’s neutrophil count should be monitoredprior to and during therapy to decrease the chanceof infection. Additional toxicities include nausea/vomiting,elevation of liver function tests, alopecia, generalized fatigue,and inappropriate secretion of antidiuretic hormone.Neurotoxicity is seen with vinorelbine but occurs to a lesserdegree compared with other vinca alkaloids because of itsdecreased affinity for axonal microtubules.

생물학적 활성

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC 50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC 50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Vinorelbine tartrate 준비 용품 및 원자재

원자재

준비 용품


Vinorelbine tartrate 공급 업체

글로벌( 322)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Hainan Xiyuan Chemical Technology Co., Ltd.
+86-15008981366
15008981366@163.com CHINA 9 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1008 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3035 58

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