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4-Methylumbelliferyl-beta-D-glucopyranoside C화학적 특성, 용도, 생산
개요
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease. Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.
화학적 성질
White Powder
용도
A fluorogenic substrate in the assay of ?-glucosidase.
Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15
정의
ChEBI: A beta-D-glucoside having a 4-methylumbelliferyl substituent at the anomeric position.
Purification Methods
4-Methylumbellifer-7-yl--Dglucopyranoside crystallises as the half hydrate from hot H2O. [Constantzas & Kocourek Collect Czech Chem Commun 24 1099 1959, De Re et al. Ann Chim (Rome) 4 9 2089 1959, Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 III/IV 5152, 8 IV 433, 18/7 V 616.]
4-Methylumbelliferyl-beta-D-glucopyranoside 준비 용품 및 원자재
