액티노마이신 D
|
|
액티노마이신 D 속성
- 녹는점
- 251-253 °C
- 끓는 점
- 848°C (rough estimate)
- 밀도
- 1.0757 (rough estimate)
- 굴절률
- 1.5700 (estimate)
- 인화점
- 87℃
- 저장 조건
- 2-8°C
- 용해도
- 에탄올, DMSO: 2-8℃에서 산성 수용액에서 안정함.
- 산도 계수 (pKa)
- 8.94±0.70(Predicted)
- 물리적 상태
- 가루
- 색상
- 빨간색, 가루
- optical activity
- [α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
- 수용성
- 녹는
- Merck
- 13,2828
- BRN
- 605235
- 안정성
- 안정적이지만 특히 희석 용액에서는 빛에 민감합니다. 강산, 강염기, 강산화제와 호환되지 않습니다. 타기 쉬운.
- CAS 데이터베이스
- 50-76-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 10, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 28-61-40-45-26/27/28 | ||
안전지침서 | 53-36/37/39-45-1-36/37-28-22 | ||
유엔번호(UN No.) | UN 3462 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | AU1575000 | ||
F 고인화성물질 | 8-10-21 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29419000 | ||
유해 물질 데이터 | 50-76-0(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 7200ug/kg |
액티노마이신 D C화학적 특성, 용도, 생산
화학적 성질
Actinomycin D is a combustible, bright red crystalline solid.용도
Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumour activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumour cell death has been demonstrated to occur by apoptosis.Indications
Dactinomycin (actinomycin D, Cosmegen) is one of a family of chromopeptides produced by Streptomyces. It is known to bind noncovalently to double-strand DNA by partial intercalation, inhibiting DNA-directed RNA synthesis. The drug is most toxic to proliferating cells, but it is not specific for any one phase of the cell cycle. Resistance to dactinomycin is caused by decreased ability of tumor cells to take up and retain the drug, and it is associated with cross-resistance to vinca alkaloids, the anthracyclines, and certain other agents (multidrug resistance).일반 설명
Bright red rhomboid prisms or red powder.공기와 물의 반응
Water soluble.반응 프로필
Actinomycin D can react with strong oxidizing agents, strong acids and strong bases.화재위험
Flash point data for Actinomycin D are not available. Actinomycin D is probably combustible.생물학적 활성
Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.Mechanism of action
Dactinomycin is cleared rapidly from plasma, does not enter the brain, is not appreciably metabolized or protein bound, and is gradually excreted in both bile and urine.Virtually no drug is detected in CSF.Clinical Use
Dactinomycin is used in curative combined treatment of Wilms’ tumor, Ewing’s sarcoma, rhabdomyosarcoma, and gestational choriocarcinoma. It is active in testicular tumors, lymphomas, melanomas, and sarcomas, although its use in most of these malignancies has been supplanted by other agents.부작용
The major side effects of dactinomycin are severe nausea, vomiting, and myelosuppression. Mucositis, diarrhea, alopecia, and radiation recall reactions may occur. The drug is immunosuppressive and carcinogenic.잠재적 노출
An antibiotic product from streptomyces, used as anticancer and veterinary drug운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Purification Methods
It crystallises as bright red rhombic crystals from absolute EtOH or from MeOH/EtOH (1:3). It will also crystallise from EtOAc/cyclohexane (m 246-247o dec), CHCl3/pet ether ( m 245-246o dec), and EtOAc/MeOH/*C6H6 (m 241-243o dec). Its solubility in MeCN is 1mg/mL. [] D varies from -296o to -327o (c 0.2, MeOH). max (MeOH) 445, 240nm (log 4.43, 4.49), max (MeOH, 10N HCl, 1:1) 477nm (log 4.21) and max (MeOH, 0.1N NaOH) 458, 344, 285 (log 3.05, 4.28, 4.13). It is HIGHLY TOXIC, light sensitive and anti-neoplastic. [Bullock & Johnson, J Chem Soc 3280 1957, Beilstein 27 III/IV 9642.]비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.액티노마이신 D 준비 용품 및 원자재
원자재
준비 용품
액티노마이신 D 공급 업체
글로벌( 275)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8820 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
액티노마이신 D 관련 검색:
트리스(하이드록시메틸)아미노메탄 글리신 6-아미노 카프로산 3-아미노페놀 시클로헥시미드 코발트(II) 아세틸아세토네이트 하이드레이트 알루미늄 아세틸아세토네이트 실버 아세틸아세토네이트 액티노마이신 D
ALTRENOGEST
ACTINOMYCIN D, 7-AMINO,7-ACTINOMYCIN C,ACTINOMYCIN D, 7-AMINO,7-ACTINOMYCIN C
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
N-BUTYLISOCYANIDE
TERT-BUTYL ISOCYANIDE
Tosylmethyl isocyanide
SALCOMINE
streptomyces avermifilis
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE