prenylamine
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prenylamine 속성
- 녹는점
- 36.5-37.5°
- 끓는 점
- 457.06°C (rough estimate)
- 밀도
- 1.0703 (rough estimate)
- 굴절률
- 1.9000 (estimate)
- 저장 조건
- Refrigerator
- 용해도
- Chloroform: slightly soluble; Methanol: slightly soluble
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- pKa 8.74±0.02(40% EtOH,t =25) (Uncertain)
- 수용성
- 50mg/L(37℃)
안전
prenylamine C화학적 특성, 용도, 생산
개요
Prenylamine is a calcium channel inhibitor. It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 μM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 μM, an effect that is negatively associated with the concentration of calmodulin. Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine . Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.화학적 성질
Pale Yellow Oil용도
Vasodilator (coronary).World Health Organization (WHO)
Prenylamine is a calcium-channel blocking agent which was introduced in 1960. It has been widely used for the prophylaxis of angina pectoris and long-term treatment of coronary heart disease. Concern about its propensity to induce dangerous cardiac dysrhythmias led the company to withdraw it from the market.prenylamine 준비 용품 및 원자재
원자재
Benzene, 1,1'-(3-chloropropylidene)bis-
1-Phenylallene
3,3-Diphenylpropiononitrile
3,3-Diphenylpropylamine
준비 용품
prenylamine 공급 업체
글로벌( 25)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 |
shchemsky@sina.com | China | 32344 | 50 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 |
sales@chem-strong.com | China | 17982 | 56 |
| Alfa Chemistry | 1-516-6625404 |
support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
sales@glpbio.cn | China | 6870 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 |
sales@rrkchem.com | China | 55672 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |