to protect retinal pigment epithelium (RPE) from oxidative stress
to show that increased expression of cell adhesion molecule 4 (CADM4) in oligodendrocytes inhibits myelination
to protect cells from apoptosis induced by shikonin plus erlotinib/gefitinib
as a component in various culture media
Biochem/physiol Actions
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.
Clinical Use
N-Acetylcysteine amide has antioxidant and is often used in the preparation of Eyedrops. It has been used as a treatment for the prevention or healing of cataracts, macular degeneration, and other degenerative eye disorders.
