ChemicalBook
Chinese English Japanese Germany Korea

플리반세린

플리반세린
플리반세린 구조식 이미지
카스 번호:
167933-07-5
한글명:
플리반세린
동의어(한글):
플리반세린
상품명:
Flibanserin
동의어(영문):
Girosa;Bimt 17;Fbanselin;BIMT 17BS;Flubanserin;Flibanserin;Filbanserin;Flibanerins;Flibaneserin;Flibanserine
CBNumber:
CB91178756
분자식:
C20H21F3N4O
포뮬러 무게:
390.4
MOL 파일:
167933-07-5.mol

플리반세린 속성

밀도
1.292±0.06 g/cm3(Predicted)
저장 조건
2-8°C
용해도
DMSO: soluble10mg/mL, clear
물리적 상태
powder
산도 계수 (pKa)
12.12±0.30(Predicted)
색상
white to beige
InChIKey
PPRRDFIXUUSXRA-UHFFFAOYSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 25-36/37/38
안전지침서 26-45
유엔번호(UN No.) UN 2811 6.1 / PGIII
WGK 독일 3
유해 물질 데이터 167933-07-5(Hazardous Substances Data)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

플리반세린 C화학적 특성, 용도, 생산

개요

Flibanserin is a drug originally developed by Boehringer-Ingelheim and later Sprout Pharmaceuticals, which was approved in 2015 by the FDA for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD). The drug, which was originally developed for the treatment of depression by Boehringer- Ingelheim, is a full agonist of the 5-HT1A receptor, an antagonist of the 5-HT2A receptor, and a partial agonist of the dopamine-4 (D4) receptor, which triggers increased dopamine and norepinephrine levels along with decreased serotonin levels. In three randomized trials involving 2400 premenopausal women, the drug was found to increase the number of satisfying sexual events by 0.5-1.0 events per month and increased sexual desire on average by 10-12% over placebo. Side effects include decreased blood pressure and loss of consciousness, especially in subjects who consumed alcohol.

용도

Antidepressant (5-HT1a agonist and 5-HT2 antagonist).

Chemical Synthesis

The large-scale synthesis of flibanserin (X) mostly follows a patent from Symed Laboratories Limited which demonstrated hundred-gram-scale preparation of the drug as described in Scheme. Starting from commercially available 1-(prop-1- en-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (74), installation of an ethylene side chain was accomplished under conventional alkylation conditions with 1,2-dibromoethane and base, and this event was immediately followed by a second alkylation reaction involving piperazine to secure piperazinyl benzimidazolone 75. Interestingly, the enamine double bond within 74 was apparently reduced to the corresponding isopropyl group under these conditions. Although the authors do not comment about this reduction directly, similar examples of olefin reduction under non-hydrogenative alkylation conditions have been reported in the literature separately by both Pai and Ryu. Removal of the isopropyl group was facilitated by means of aqueous sodium hydroxide to afford 76, which underwent N-arylation under Buchwald conditions with 1-bromo-3-(trifluoromethyl)benzene 77 to furnish flibanserin (X) in 63% yield.

플리반세린 준비 용품 및 원자재

원자재

준비 용품


플리반세린 공급 업체

글로벌( 255)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Hong Kong Tiansheng New Material Trading Co., Ltd
+8617320695765
17320695765 zxx@hktiansheng.com China 337 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Hebei Miaobian Biotechnology Co., Ltd
17733850068 +8617733850068
Iglesia@cnhbmiaobian.com CHINA 873 58
Baoji Guokang Bio-Technology Co., Ltd.
09173909592
09173909592 cngksw@aliyun.com CHINA 9446 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
rebecca@tgybio.com CHINA 1218 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60

플리반세린 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved