1,3-Dimethylbarbituric acid
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1,3-Dimethylbarbituric acid 속성
- 녹는점
- 121-123 °C (lit.) 121-123 °C
- 끓는 점
- 228.1±23.0 °C(Predicted)
- 밀도
- 1.322±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C Freezer
- 용해도
- 뜨거운 물: 용해성0.5g/10mL, 투명, 무색 내지 희미한 노란색
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- pK1:4.68(+1) (25°C)
- 색상
- 화이트/크림/옅은 노란색
- 수용성
- 물에 용해됩니다.
- BRN
- 139810
- CAS 데이터베이스
- 769-42-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
1,3-Dimethylbarbituric acid C화학적 특성, 용도, 생산
화학적 성질
Yellow or brownish powder용도
1,3-Dimethylbarbituric acid is used as a catalyst in the Knoevenagel condensation of a series of aromatic aldehydes. It is also used in the synthesis of 5-aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives and enantioselective synthesis of isochromene pyrimidinedione derivatives.일반 설명
1,3-Dimethylbarbituric acid (1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione) is an active methylene compound. It undergoes hollow Pd6 water-soluble cage, [{(tmen)Pd}6(timb)4](NO3)12 (tmen= N,N,N′,N′-tetramethylethylenediamine, timb=1,3,5-tris(1-imidazolyl)benzene)-catalyzed Knoevenagel condensation reaction with pyrene-1-carboxaldehyde. It undergoes self-sorted Pd7 molecular boat having an internal nanocavity (catalyst)-assisted Knoevenagel condensation reaction with various aromatic aldehydes. It has been synthesized by reacting 1,3-dimethylurea, malonic acid and acetic anhydride in acetic acid. It is widely used for the synthesis of various synthetic intermediates and heterocyclic compounds.Purification Methods
Crystallise the acid from water and sublime it in a vacuum. Also purify it by dissolving 10g in 100mL of boiling CCl4/CHCl3 (8:2) (1g charcoal), filtering and cooling to 25o. Dry it in vacuo [Kohn et al. Anal Chem 58 3184 1986]. [Beilstein 24 III/IV 1875.]1,3-Dimethylbarbituric acid 준비 용품 및 원자재
원자재
준비 용품
6-[N-(2-Hydroxyethyl)amino]-1,3-dimethyl-2,4(1H,3H)-dione
ISOCAFFEINE
1,3-dimethyl-5-(thiophen-2-ylmethylene)pyrimidine-2,4,6(1H,3H,5H)-trione
7-AMINO-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRANO[2,3-D]PYRIMIDINE-5,5,6-TRICARBONITRILE
5-((1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
2-[(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]phenyl acetate
1,3-dimethyl-5-[(4-oxo-4H-chromen-3-yl)methylidene]-1,3-diazinane-2,4,6-trione
1,3-DIMETHYL-5-([4-(METHYLSULFANYL)PHENYL]METHYLENE)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
6-chloro-1,3-dimethyl-5-nitro-pyrimidine-2,4-quinone
1,3-DIMETHYL-5-[(DIMETHYLAMINO)METHYLENE]2,4,6-(1H,3H,5H)-TRIOXOPRYIMIDINE
1,3-Dimethylbarbituric acid 공급 업체
글로벌( 370)공급 업체
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