N-Hydroxy-5-norbornene-2,3-dicarboximide
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N-Hydroxy-5-norbornene-2,3-dicarboximide 속성
- 녹는점
- 165-170 °C (lit.)
- 끓는 점
- 311.69°C (rough estimate)
- 밀도
- 1.2822 (rough estimate)
- 굴절률
- 1.5600 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- 에탄올에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 9.00±0.20(Predicted)
- 색상
- 회백색
- BRN
- 13540
- CAS 데이터베이스
- 21715-90-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
N-Hydroxy-5-norbornene-2,3-dicarboximide C화학적 특성, 용도, 생산
개요
N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.화학적 성질
white to off-white crystalline powder용도
N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.Purification Methods
Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]N-Hydroxy-5-norbornene-2,3-dicarboximide 준비 용품 및 원자재
원자재
준비 용품
N-Hydroxy-5-norbornene-2,3-dicarboximide 공급 업체
글로벌( 262)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Nanjing Triumpharm Co.,Ltd | +86-02586182925 +86-15105172550 |
info@triumpharm.com | China | 129 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| AB PharmaTech,LLC | 323-480-4688 |
United States | 989 | 55 | |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10248 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
N-Hydroxy-5-norbornene-2,3-dicarboximide 관련 검색:
숙신산이미드 4,4'-디페닐메탄 비스-말린이미드 프탈이미드 N-클로로숙신이미드 노보넨모노머 다이알리포르(디알리포르)
CHLOROPHOSPHONAZO III
Dispersing agent 155
Polyamideimide
HNTU
2-(5-Norborene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium tetrafluoroborate
5-NORBORNENE-2,3-DICARBOXIMIDE
5-Norbornene-2,3-dicarboxylic acid
5-Norbornene-2-endo,3-exo-dicarboxylic acid
EXO-NORBORNEOL
ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 97
N-BENZYLOXYCARBONYLOXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 99
N-Hydroxy-5-norbornene-2,3-dicarboximide