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황산마그네슘

황산마그네슘
황산마그네슘 구조식 이미지
카스 번호:
7487-88-9
한글명:
황산마그네슘
동의어(한글):
황산마그네시아;마그네슘황산염용액2.25%;에프솜염;황산마그내슘;황산마그네슘;황산마그네슘염(1:1);황산마그네슘(1:1);황산,마그네슘염;황산마그네슘
상품명:
Magnesium sulfate
동의어(영문):
DBO2;MgSO4;Salts;Dried;Nsc146179;Hair salt;Sal amarum;salangalis;TBS TABLETS;Wln: mg S-o4
CBNumber:
CB9122608
분자식:
MgSO4
포뮬러 무게:
120.37
MOL 파일:
7487-88-9.mol

황산마그네슘 속성

녹는점
1124 °C
밀도
1.07 g/mL at 20 °C
증기 밀도
<0.01 (vs air)
증기압
<0.1 mm Hg ( 20 °C)
저장 조건
Store at room temperature.
용해도
H2O: 1 M at 20 °C, clear, colorless
물리적 상태
powder (very fine)
색상
slightly gray
Specific Gravity
2.66
수소이온지수(pH)
7.9 (50g/l, H2O, 25℃)
수용성
Soluble in water. Slightly soluble in alcohol, glycerol. Insoluble in acetone.
최대 파장(λmax)
λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.02
감도
Hygroscopic
Merck
14,5691
안정성
Stable. Hygroscopic.
CAS 데이터베이스
7487-88-9(CAS DataBase Reference)
NIST
Magnesium sulfate(7487-88-9)
EPA
Sulfuric acid magnesium salt (1:1)(7487-88-9)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 22-24/25-36-26
WGK 독일 1
RTECS 번호 OM4500000
F 고인화성물질 3
TSCA Yes
HS 번호 28332100
유해 물질 데이터 7487-88-9(Hazardous Substances Data)

황산마그네슘 MSDS


Magnesium sulfate

황산마그네슘 C화학적 특성, 용도, 생산

물성

수용성의 쓴맛이 나는 무색 결정. MgSO4. 무수염 외에 1, 2, 4, 5, 6, 7 및 12 수화물이 알려져 있다. 가장 보편적인 것은 7수화물이며 사리염 또는 엡솜염이라 불린다. 오래 전부터 완화제로 알려져 있다. 종이의 충전제, 내화제, 매염제, 의약품, 마그네슘 비료로 사용된다.

용도

1) 공업적으로는 해수 또는 칼리 공업에서 부차 생성된다. 독일에서는 칼륨염 채취시 결정하는 키제르석을 뜨거운 물에 녹이고 용액을 정치 냉각하여 7수화염을 결정화시키고 있다. 2) 산화마그네슘 또는 히드록시탄산마그네슘을 황산에 녹인 후 미량으로 존재하는 중금속 불순물을 제거하기 위해 마그네슘염을 약간 과잉으로 가해 가열해서 거른다. 모액을 다시 농축하여 공랭하면 7수화염이 결정화한다. 이것을 걸러, 분리하여 자연 건조한다. 3) 무수염은 함수염을 적열 탈수하여 얻어진다.

용도

종이의 충전제, 비단의 증가량제, 내화 목면천의 제조, 매염제, 의약으로서 이용된다. 6국 기재의 의약품 : MgSO4ㆍ7H2O. 강열할 때 MgSO4로서 99.5% 이상 함유. 염류 하제로서 내복. 용량 : 1회 8g, 1일 15g. 경련 진정, 진통, 마취 목적에서는 주사제로서 보통 1회 1g을 이용한다.

개요

Magnesium sulfate is an inorganic salt (chemical compound) containing magnesium, sulfur and oxygen, with the formula MgSO4. It is strongly hygroscopic and often encountered as the heptahydrate sulfate mineral epsomite (MgSO4•7H2O), commonly called Epsom salt. And the monohydrate, MgSO4•H2O, is found as the mineral kieserite. In gardening and other agriculture, magnesium sulfate is used to correct a magnesium or sulfur deficiency in soil. In food preparation, magnesium sulfate is used as a brewing salt in beer production or used as a coagulant for making tofu. In chemistry, anhydrous magnesium sulfate is commonly used as a desiccant in organic synthesis due to its affinity for water. For Marine use, magnesium sulfate heptahydrate is used to maintain the magnesium concentration in marine aquaria which contain large amounts of stony corals. For medicine use, it is used in pregnant women to control seizures due to certain complications of pregnancy (eg, severe toxemia) and to control high blood pressure, severe brain function problems (encephalopathy), and seizures in children who have sudden, severe inflammation of the kidneys (acute nephritis). Besides, magnesium sulfate is also used as a laxative to relieve occasional constipation.

화학적 성질

Magnesium sulfate (MgS04) is a colorless crystal with a bitter, saline taste. It is soluble in glycerol and used in fireproofing, textile processes, ceramics, cosmetics, and fertilizers.

물리적 성질

In their hydrated form, these salts have a pH of 6.0 (5.5 to 6.5) in solution. These magnesium sulfates are white crystalline solids. Their densities are: 2.66 g/cm3 (anhydrous); 2.445 g/cm3 (monohydrate); 1.68 g/cm3 (heptahydrate). Solubilities in water are: anhydrous= 26.9 g/100 ml (0°C); monohydrate= 25.5 g/100 ml (20°C); heptahydrate=71 g/100 ml (20°C). Magnesium sulfate is found in nature in many salt deposits and mineral waters, occurring as hydrates or double salts. The heptahydrate or Epsom salt was discovered in 1695, found inthemineralwater at Epsom. Kieserite and epsomite are the two most important minerals. Other than these and the above hydrates, magnesium sulfate is also found in several other minerals, including langbeinite, leonite,vanthoffite,bloedite,kainite,polyhalite,

용도

In agriculture and gardening, magnesium sulfate is used to correct magnesium deficiency in soil, since magnesium is an essential element in the chlorophyll molecule. It is most commonly applied to potted plants, or to magnesium-hungry crops, such as potatoes, tomatoes, peppers, and roses. The advantage of magnesium sulfate over other magnesium compounds (such as dolomitic limestone) is its high solubility. MgSO4 has been used in organic synthesis to remove water from nonaqueous solutions before the organic reaction is started. Since it is insoluble in most organic solvents, its addition forms hydrates that can be easily removed.
Epsom salt is also used to prepare footbaths, intended to soothe sore feet. The reason for the inclusion of the salt is partially cosmetic. However, magnesium sulfate can also be absorbed into the skin, reducing inflammation. It is also sometimes found in bottled mineral water, and accordingly is sometimes listed in the contents thereof. Magnesium sulfate heptahydrate is also used to maintain the magnesium concentration in marine aquaria which contain large amounts of stony corals as it is slowly depleted in their calcification process, precipitation into calcium carbonate. Oral Epsom salt is used as a saline laxative as well as for replacement therapy in “hypomagnesaemia” (lack of Mg2+) in animals and humans. Magnesium sulfate paste has been used as an agent for dehydrating (drawing) boils, carbuncles or abscesses. Magnesium sulfate solution has also been shown to be an effective aid in the fight against blemishes and acne when applied directly to problematic areas. Magnesium sulfate, when used through soaking, can soothe muscle pains and help improve rough patches in the skin. Soaking in a warm bath containing Epsom salt (magnesium sulfate) can be beneficial to soothe and relieve herpes outbreak symptoms, such as itching and lesions relating to genital herpes or shingles.

용도

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency,

용도

magnesium sulfate is an inorganic salt used as a bulking agent in cosmetic preparations.

용도

Magnesium sulfate, a mild central nervous system (CNS) depressant and vasodilator, is used for eclamptic seizures. An initial intravenous loading dose is 2 to 4 g administered over 15 minutes, followed by a continuous infusion of 1 to 3 g/hour. The therapeutic serum level is 4 to 8 mEq/L.

용도

Magnesium sulfate has been used for decades as a tocolytic; however recently it has been noted that given its lack of benefit, possible harms, and expense, magnesium sulfate should not be used for tocolysis.

용도

Magnesium sulfate is used widely in several industries including fertilizer, cement, textile, chemicals, and medicine. In the cement industry, it is used in manufacturing oxysulfate cement. In medicine, it is an analgesic and cathartic. An important application of anhydrous magnesium sulfate in the laboratory involves drying organic solvents required for syntheses and GC analysis.
In the textile industry, magnesium sulfate is used in finishing composition for dressing cotton; for weighting and sizing silk; as a mordant for fixing basic dyestuffs on wool; and in fireproofing fabrics. It also is a component of certain types of electrolytic plating baths; of various photographic solutions; of cosmetic lotions. It is a catalyst carrier; a dietary supplement in cattle feed; a coagulant for rubber and plastic; and is used in making citric acid and several magnesium salts, such as magnesium stearate.

제조 방법

Hydrated magnesium sulfate occurs in nature as the minerals kieserite and epsomite. The salt is mined in large scale from these and other naturally occurring minerals. The salt also is prepared in the laboratory by the action of sulfuric acid on magnesium oxide, hydroxide, or carbonate followed by evaporation and crystallization:
MgO + H2SO4 → MgSO4 + H2O
Mg(OH)2 + H2SO4 → MgSO4 + 2H2O
MgCO3 + H2SO4 → MgSO4 + CO2 + H2O
Crystallization at temperatures between 1.8 and 48°C yields heptahydrate, MgSO4•7H2O. Below 1.8°C, a dodecahydrate , MgSO4•12H2O crystallizes out. Above 48°C crystals of lower hydrates form. The anhydrous salt is obtained by heating the heptahydrate at about 500°C in a rotary drum; or dehydrating above 150°C in the presence of sulfuric acid.

주요 응용

Magnesium sulfate is utilized in the potassium chemicals industry for the manufacture of potassium sulfate (from potassium chloride), sodium sulfate and potash magnesia (potassium magnesium sulfate). Magnesium sulfate, particularly as kieserite, is used as a fertilizer (ca. 80% of total consumption). It is also used in the textile industry, in the manufacture of building and refractory materials, in the pulp industry and in the production of animal feedstuffs and motor oil additives.

생산 방법

Magnesium sulfate is widely distributed in nature, e.g. in salt deposits as kieserite, as Epsom salt MgSO4 . 7H20, in the form of double salts such as kainite 4KCl . 4MgSO4 . 11H20 and langbeinite K2SO4 . 2MgSO4, and in brines. Large quantities of kieserite, Epsom salt and anhydrous magnesium sulfate are produced in the processing of potassium salts. Magnesium sulfate is also produced by reacting magnesium carbonate or seawatermagnesium hydroxide with sulfuric acid.

정의

ChEBI: A magnesium salt having sulfate as the counterion.

Indications

Magnesium sulfate prevents convulsions in preeclampsia and directly uncouples excitation–contraction in myometrial cells through inhibition of cellular action potentials. Furthermore, magnesium sulfate decreases calcium uptake by competing for its binding sites, activating adenylyl cyclase (thereby reducing intracellular calcium), and stimulating calcium-dependent adenosine triphosphatase (ATPase), which promotes calcium uptake by the sarcoplasmic reticulum. Magnesium is filtered by the glomerulus, so patients with low glomerular filtration will have low magnesium clearance. Although the compound does have some cardiac side effects, magnesium sulfate may be preferred over β- adrenergic agents in patients with heart disease, diabetes, hypertension, or hyperthyroidism.

Biological Functions

Magnesium sulfate may be effective in terminating refractory ventricular tachyarrhythmias, particularly polymorphic ventricular tachycardia. Digitalis-induced arrhythmias are more likely in the presence of magnesium deficiency. Magnesium sulfate can be administered orally, intramuscularly, or, preferably, intravenously,when a rapid response is intended.The loss of deep tendon reflexes is a sign of overdose.

농업용

Magnesium sulphate is a white compound existing both in anhydrous (rhombic) and hydrated crystalline forms. The monohydrate MgSO4·H2O (monoclinic) occurs in nature as kieserite. It is a greyish-white crystalline powder which contains about 16 % magnesium and is used as a fertilizer. It is regarded as a concentrated form of epsom salt, having less water of crystallization. The commonest hydrate is heptahydrate MgSO4·7H2O(also called rhombic or epsom salt) which occurs naturally as the mineral epsomite. It is a white powder with a bitter, saline taste. The salt in the monocliic form loses its structural water at 150°C, while the rhombic form loses water at 200°C.
Magnesium sulphate is used in sizing and freproofng cotton and silk, in tanning leather, in the manufacture of fertilizers, in explosives and matches, in medicines as a laxative, and as a veterinary medicine for the treatment of inflammations and infected wounds.

Clinical Use

There is much debate as to the efficacy of magnesium sulfate. For effective inhibition of uterine activity, enough must be given to maintain a blood plasma level of at least 5.5 mEq/L. Even at this level, tocolysis may be hard to achieve.

부작용

Magnesium toxicity can be life threatening. Patients given magnesium lose patellar reflexes at plasma levels greater than 8 to 10 mEq/L.Respiratory depression can occur at levels greater than 10 to 12 mEq/L, with respiratory paralysis and arrest soon after (e.g., at levels greater than 12–15 mEq/L). Higher levels cause cardiac arrest. Toxicity can be avoided by following urine output and checking patellar reflexes in patients receiving magnesium. Other side effects include sweating, warmth, flushing, dry mouth, nausea, vomiting, dizziness, nystagmus, headache, palpitations, pulmonary edema, maternal tetany, profound muscular paralysis, profound hypotension, and neonatal depression.

부작용

The side effects of magnesium sulfate administration are dose dependent. As magnesium levels increase, skeletal muscle weakness increases and CNS depression and vascular dilation occur. Magnesium sulfate infusion commonly results in a slight decrease in blood pressure during epidural anesthesia.
Cardiac muscle is not affected to a clinically evident degree when magnesium is administered at therapeutic levels, although magnesium can have profound myocardial effects during a gross overdose.
Magnesium antagonizes the vasoconstrictive effect of α-agonists, so ephedrine and phenylephrine are likely to less effectively increase maternal blood pressure when administered concomitantly with magnesium.
Magnesium is eliminated unchanged by the kidneys. In a patient who is receiving a maintenance infusion of magnesium and who has decreasing urine output, blood levels of magnesium quickly increase, as do related side effects.
Other side effects of magnesium sulfate include the following: (1) Cutaneous vasodilation with flushing (2) Headache and dizziness (3) Nausea (4) Skeletal muscle weakness (5) Depression of deep tendon reflexes (6) Respiratory depression (7) ECG changes

Safety Profile

A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects: heart changes, cyanosis, flaccid paralysis with appropriate anesthesia. An experimental teratogen. Mutation data reported. Potentially explosive reaction when heated with ethoxyethynyl alcohols (e.g., l-ethoxy 3-methyl-1-butyn-3-01). When heated to decomposition it emits toxic fumes of SOx. See also SULFATES.

Purification Methods

Crystallise it from warm H2O (1g/mL) by cooling. Dry the heptahydrate (Epsom salt) at ~250o until it loses 25% of its weight. Its solubility in H2O is 36% at 20o, 55% at 60o and 74% at 100o; above 110o the solubility decreases with rise of temperature. Store it in a sealed container.

주의 사항

Magnesium sulfate is not for use in patients with heart block or extensive myocardial damage. Use it with caution in patients with impaired renal function, in digitalized patients, and with concomitant use of other central nervous system depressants or neuromuscular blocking agents. Intravenous administration is contraindicated during the 2 hours preceding delivery. Oral administration is contraindicated in patients with abdominal pain, nausea, vomiting, fecal impaction, or intestinal irritation, obstruction, or perforation.

참고 문헌

1. https://en.wikipedia.org/wiki/Magnesium_sulfate
2. https://www.drugs.com/cdi/magnesium-sulfate.html
3. https://pubchem.ncbi.nlm.nih.gov/compound/magnesium_sulfate
4. http://www.emedicinehealth.com/drug-magnesium_sulfate/article_em.htm

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