Retatrutide

Retatrutide C화학적 특성, 용도, 생산

개요

Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.
Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.
Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.
Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.

생물학적 활성

Retatrutide (LY3437943), a single peptide conjugated to a lipid diacid molecule, exerts a powerful agonist effect on the human glucagon‐receptor (GCGR), GIPR, and GLP‐1R. In comparison with the human glucagon and glucagon‐like peptide 1 (GLP‐1), retatrutide exhibits reduced potency (by a factor of 0.3 and 0.4, respectively) on the GCGR and GLP‐1R while displaying enhanced potency at the human GIPR (by a factor of 8.9) when compared to the glucose‐dependent insulinotropic polypeptide (GIP)[7].

부작용

The most common side effects of retatrutide are gastrointestinal, including: Nausea, Diarrhea, Vomiting, and Constipation. At higher doses, researchers stated these symptoms were "mostly mild to moderate in severity" and typically treated by lowering the dosage. However, 7% of patients also experienced skin tingling. At 24 weeks of treatment, patients' heart rates on higher doses peaked but declined afterward.

Retatrutide 준비 용품 및 원자재

원자재

준비 용품

Retatrutide 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2556	58
Hubei Yuanao Technology CO Ltd	+86-15377628618	info@yuanaotech.com	China	6	58
Huaian Banting Trading Co., Ltd.	+8615833979905	sales2@bantingpeptide.com	China	85	58
Hebei Xunou new energy Technology Co., LTD	+86-17531957005; +undefined17531957005	xunou8@hbxunou.com	China	36	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18134017493	sunflowerfranklin20@gmail.com	China	14	58
Sea Biological Co.,LTD	+8613865152372	tim@sea-biol.com	China	71	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	295	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	884	58
S&Y Biochem Co.,Ltd	+86-17774091612; +8617774091612	marketing@sybiochem.com	China	295	58
Hubei KDG Web Science&Technology Co., Ltd	18672314556 +8618672314556	sales@kdg-tech.com	China	933	58

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