kaurenoic acid

kaurenoic acid 구조식 이미지
카스 번호:
6730-83-2
상품명:
kaurenoic acid
동의어(영문):
NSC 339145;kaurenoate;Cunabic acid;kaurenoic acid;Kauren-19-oic acid;ent-kaur-16-en-19-oicaci;Kaurane-16-ene-18-oic acid;(-)-Kaur-16-en-18-oic acid;ent-Kaur-16-en-19-oic acid;Kaur-16-en-18-oic acid,(4a)-
CBNumber:
CB91316121
분자식:
C20H30O2
포뮬러 무게:
302.45
MOL 파일:
6730-83-2.mol
MSDS 파일:
SDS

kaurenoic acid 속성

녹는점
171-172 °C
끓는 점
426.6±34.0 °C(Predicted)
밀도
1.10±0.1 g/cm3(Predicted)
저장 조건
Sealed in dry,Store in freezer, under -20°C
용해도
DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 10 mg/ml
물리적 상태
고체
산도 계수 (pKa)
4.70±0.40(Predicted)

안전

WGK 독일 3

kaurenoic acid C화학적 특성, 용도, 생산

개요

Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.

용도

ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.

정의

ChEBI: An ent-kaurane diterpenoid that is ent-kauran-19-oic acid in which a double bond is present at position 16(17); exhibits anticancer and anti-HIV 1 activity.

kaurenoic acid 준비 용품 및 원자재

원자재

준비 용품


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