리스페리돈
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리스페리돈 속성
- 녹는점
- 170°C
- 끓는 점
- 572.4±60.0 °C(Predicted)
- 밀도
- 1.38±0.1 g/cm3(Predicted)
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥5mg/mL
- 산도 계수 (pKa)
- pKa 8.3 (Uncertain)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 44.74mg/L(25℃)
- Merck
- 14,8233
- BCS Class
- 2
- CAS 데이터베이스
- 106266-06-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,F | ||
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위험 카페고리 넘버 | 25-39/23/24/25-23/24/25-11 | ||
안전지침서 | 28-36-45-36/37-16 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UV1164800 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29333990 | ||
유해 물질 데이터 | 106266-06-2(Hazardous Substances Data) | ||
독성 | LD50 in male, female mice, rats, dogs (mg/kg): 29.7, 26.9, 34.3, 35.4, 14.1, 18.3 i.v.; 82.1, 63.1, 113, 56.6, 18.3, 18.3 orally (Janssen, 1988) |
리스페리돈 C화학적 특성, 용도, 생산
개요
Risperidone is a novel antipsychotic introduced for the treatment of acute and chronic schizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonist activity. While the anti-D2 activity may relate to the antipsychotic potency of neuroleptic agents, an antidepressive efficacy of substances with anti-5-HT2 activity has been suggested. Risperidone, therefore, has therapeutic action on both positive and negative symptoms of schizophrenia and produces significantly fewer side effects especially extrapyramidal symptoms compared with commonly used pure D2 antagonist antipsychotics. It also has potential for management of alcohol withdrawal and cocaine addiction.화학적 성질
Crystalline Solid용도
Risperidone has been used:- to study its effects on bone formation and differentiation
- to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients
- to reverse induced schizophrenia-like behavior in mice
정의
ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.일반 설명
Risperidone (Risperdal, a benzisoxazole)has the structural features of a hybrid molecule between abutyrophenone antipsychotic and a trazodone-like antidepressant.Its superior side effects profile (compared withhaloperidol) at dosage of 6 mg/d or less and the lower riskof tardive dyskinesia have contributed to its very widespreaduse. It benefited refractory psychotic patients, withparkinsonism controlled at one tenth the dose of antiparkinsoniandrugs used with haloperidol.Coexisting anxietyand depressive syndromes were also lessened. It is reportedto decrease the negative (e.g., withdrawal, apathy) as well asthe positive (e.g., delusions, hallucinations) symptoms ofschizophrenia. This is reportedly a consequence of the compound’scombination 5-HT2–D2 receptor antagonistic properties.Overall, the reasons for the decreased EPS and effectiveness against negative symptom are still under investigation.It is an important atypical antipsychotic.Risperidone is metabolized in the liver by CYP2D6 to anactive metabolite, 9-hydroxyrisperidone. Because thismetabolite and risperidone are nearly equipotent, the clinicalefficacy of the drug reflects both compounds.생물학적 활성
Atypical antipsychotic agent that displays 5-HT 2A receptor antagonism. Also displays high affinity at D 2 receptors (K i values are 0.4 and 3.13 nM for 5-HT 2A and D 2 receptors respectively).리스페리돈 준비 용품 및 원자재
원자재
요오드화 칼륨
이소옥사졸
4-Pyrimidinol
디플르오르벤젠(1,3-)
885706-66-1
Risperidal iMpurity B
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyiMino)Methyl]-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one
Risperidone E-Oxime
2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime
2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole
테트라시아노에틸렌
준비 용품
리스페리돈 공급 업체
글로벌( 558)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
리스페리돈 관련 검색:
할로페리돌 드로페리돌, 펜타닐 에틸파라벤 초산에틸 트리넥사팩-에틸 에틸 5,5-디페닐-2-이소사졸린-3-카르복실레이트 에틸렌글리콜 모노에틸 에테르 에틸알코올 플루오린(불소) 1,2-벤지속사졸 리스페리돈
Triacetonediamine
6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE(FOR RISPERIDONE&ILOPERIDONE)
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Diphenoxylate
Paliperidone
4-(2,4-Difluorobenzoyl)-piperidine hydrochloride