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프로베네시드

프로베네시드
프로베네시드 구조식 이미지
카스 번호:
57-66-9
한글명:
프로베네시드
동의어(한글):
프로베네시드
상품명:
Probenecid
동의어(영문):
Proben;Apurina;benacen;Benemid;Benuryl;Uricosid;Tubophan;DRG-0053;benemide;probalan
CBNumber:
CB9134579
분자식:
C13H19NO4S
포뮬러 무게:
285.36
MOL 파일:
57-66-9.mol

프로베네시드 속성

녹는점
194-196°C
밀도
1.2483 (rough estimate)
굴절률
1.6800 (estimate)
저장 조건
Store at RT
산도 계수 (pKa)
5.8(at 25℃)
물리적 상태
neat
수용성
<0.1 g/100 mL at 20 ºC
Merck
14,7754
안정성
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
CAS 데이터베이스
57-66-9(CAS DataBase Reference)
NIST
P-(dipropylsulfamoyl) benzoic acid(57-66-9)
EPA
Benzoic acid, 4-[(dipropylamino)sulfonyl]- (57-66-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-40
안전지침서 36/37-24/25
유엔번호(UN No.) 3249
WGK 독일 3
RTECS 번호 DG9400000
TSCA Yes
HS 번호 29350090
유해 물질 데이터 57-66-9(Hazardous Substances Data)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

프로베네시드 MSDS


4-[(Dipropylamino)sulfonyl]benzoic acid

프로베네시드 C화학적 특성, 용도, 생산

화학적 성질

White to Off-White Solid

용도

pharmaceutical intermediate

용도

For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administra

용도

An inhibitor of several ABC-transporters of the subfamily ABCC or MRP.

용도

Uricosuric drug.

Indications

When probenecid (ColBENEMID) is given in sufficient amounts, it will block the active reabsorption of uric acid in the proximal tubules following its glomerular filtration, thereby increasing the amount of urate eliminated. In contrast, low dosages of probenecid appear to compete preferentially with plasma uric acid for the proximal tubule anionic transport system and thereby block its access to this active secretory system. The uricosuric action of probenecid, however, is accounted for by the drug’s ability to inhibit the active reabsorption of filtered urate.

정의

ChEBI: A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

상표명

Benemid (Merck); Probalan (Lannett).

일반 설명

Probenecid (Benemid) is the most widely used uricosuricagent in the United States. It is selectively excreted into therenal tubules by OATS. It is extensively metabolized via Ndealkylationor ω-oxidation, followed by phase II conjugationinto the active metabolite, p-sulfamyl hippurate, whichexhibits a high affinity, similar to p-aminohippurate, forbinding to OATS, thereby preventing uric acid reabsorptionfrom the renal proximal tubules.

일반 설명

Odorless white or almost white crystalline powder. Slightly bitter taste; pleasant aftertaste.

공기와 물의 반응

Insoluble in water.

반응 프로필

Probenecid may be light sensitive .

화재위험

Flash point data for Probenecid are not available. Probenecid is probably combustible.

Mechanism of action

Probenecid is rapidly absorbed after oral administration, with peak plasma levels usually reached in 2 to 4 hours. Its half-life is somewhat variable (6–12 hours) because of both its extensive plasma protein binding and its active proximal tubular secretion. Since tubular backdiffusion is decreased at alkaline urinary pH ranges, probenecid excretion increases with increasing urinary pH. Probenecid is rapidly metabolized, with less than 5% of an administered dose being eliminated in 24 hours.The major metabolite is an acyl monoglucuronide.

Clinical Use

Probenecid is an effective and relatively safe agent for controlling hyperuricemia and preventing tophi deposition in tissues. Chronic administration will decrease the incidence of acute gouty attacks as well as diminish the complications usually associated with hyperuricemia, such as renal damage and tophi deposition.
Probenecid is still used by some physicians to maintain high blood levels of penicillin, cephalosporin, acyclovir, and cyclosporine. It is not useful in treating acute attacks of gouty arthritis. If the total amount of uric acid excreted is greater than 800 mg/day, the urine should be alkalinized to prevent kidney stone formation and promote uric acid.

Veterinary Drugs and Treatments

Although there has been very limited clinical use or research on probenecid in veterinary medicine, it can be useful in treating gout (hyperuricemia), particularly in reptiles.
Probenecid’s effect in inhibiting renal tubular secretion of certain beta-lactam antibiotics and other weak organic acids is of interest for increasing serum concentrations, or reducing doses and dosing frequency of these drugs. This may allow greater efficacy (but also toxic effects) and reduce the cost or dosing frequency of expensive human drugs. Probenecid has a significantly long elimination halflife in dogs (about 18 hours), which may make it particularly useful in this species; however, at present there is little research supporting this use of probenecid in veterinary patients.

프로베네시드 준비 용품 및 원자재

원자재

준비 용품


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