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석시머

석시머
석시머 구조식 이미지
카스 번호:
304-55-2
한글명:
석시머
동의어(한글):
석시머
상품명:
Succimer
동의어(영문):
DMSA;chemet;dim-sa;ro1-7977;SUCCIMER;MESO-DMSA;API Succimer;2,3-Dimercaptosuccinic;2,3-DITHIOSUCCINICACID;meso-2,3-dithiosuccinicacid
CBNumber:
CB9142563
분자식:
C4H6O4S2
포뮬러 무게:
182.22
MOL 파일:
304-55-2.mol

석시머 속성

녹는점
196-198 °C (dec.)(lit.)
끓는 점
285.62°C (rough estimate)
밀도
1.439 (estimate)
굴절률
1.5220 (estimate)
저장 조건
−20°C
산도 계수 (pKa)
pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
물리적 상태
Powder
색상
White to off-white
수용성
Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
Merck
14,8865
BRN
1725150
안정성
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
ACTRVOBWPAIOHC-XIXRPRMCSA-N
CAS 데이터베이스
304-55-2(CAS DataBase Reference)
EPA
Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel-(304-55-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 24/25-36-26
WGK 독일 2
RTECS 번호 WM7650000
F 고인화성물질 10-23
TSCA Yes
HS 번호 29309090
유해 물질 데이터 304-55-2(Hazardous Substances Data)
독성 LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

석시머 C화학적 특성, 용도, 생산

개요

Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.

화학적 성질

white or off-white powder

Originator

Johnson and Johnson (J&J) (U.S.A.)

용도

A selective masking agent for cadmium in EDTA titration of zinc.

용도

chelating agent, antihypertensive

용도

meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.

용도

chelating agent, treatment of lead poisoning

용도

A water-soluble chelating agent.

용도

Chelating agent.

정의

ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.

상표명

Chemet (Ovation).

Pharmaceutical Applications

Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.

Pharmaceutical Applications

The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.

Veterinary Drugs and Treatments

In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended.

Purification Methods

Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]

석시머 준비 용품 및 원자재

원자재

준비 용품


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