Avanafil
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Avanafil 속성
- 녹는점
- 150-152°C
- 밀도
- 1.372
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.84±0.46(Predicted)
- 색상
- 흰색에서 황백색까지
- InChIKey
- WEAJZXNPAWBCOA-INIZCTEOSA-N
- SMILES
- C1(N2CCC[C@H]2CO)=NC=C(C(NCC2=NC=CC=N2)=O)C(NCC2=CC=C(OC)C(Cl)=C2)=N1
- CAS 데이터베이스
- 330784-47-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Avanafil C화학적 특성, 용도, 생산
개요
Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.화학적 성질
White Solid용도
Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.정의
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine Used for treatment of erectile dysfunction.Clinical Use
Avanafil was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil, which is an oral PDE5 inhibitor for the treatment of erectile dysfunction (ED). Although many marketed PDE5 inhibitors (e.g. sildenafil, vardenafil and tadalafil) are available for the treatment of ED, many patients are still unable to achieve the desired results and experience undesired side-effects with these existing medications. As such, second-generation PDE5 inhibitors with enhanced PDE5 selectivity, shorter systemic half-lives, and improved tolerability are desired. Developed to meet these criteria, Avanafil exhibited good oral bioavailability and PDE5 selectivity in both preclinical studies and clinical trials. Avanafil had a short onset of action (35 min) and short half-life (1.5 h).Avanafil 준비 용품 및 원자재
원자재
5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]-
2-PYRIMIDINEMETHANAMINE
L-프롤린올
준비 용품
Avanafil 공급 업체
글로벌( 428)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
| Wuhan Marco Pharmaceutical Technology Co., Ltd. | +86-86-18572802410 +8618572802410 |
sales@marcopht.com | China | 55 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1532 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
| Wuhan Mayue Longteng Technology Development Co., Ltd. | +undefined15171477138 |
helen.yan@lantu-tech.com | China | 287 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 |
mike@ge-tian.com | China | 272 | 58 |
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 |
Ethan@dornechem.com | China | 294 | 58 |
| Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 |
sales@cellwh.com | China | 376 | 58 |