겜핍로질
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겜핍로질 속성
- 녹는점
- 61-63°C
- 끓는 점
- 158-159 C
- 밀도
- 1.1109 (rough estimate)
- 굴절률
- 1.5020 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물에는 거의 녹지 않으며, 염화메틸렌에는 잘 녹고, 무수 에탄올과 메탄올에는 잘 녹습니다.
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.75±0.45(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- >0.5g/L(온도는 명시되지 않음)
- Merck
- 14,4388
- BCS Class
- 2
- CAS 데이터베이스
- 25812-30-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 66) 1996
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-63-62-46-36/38-21 | ||
안전지침서 | 36-53-36/37-26-25 | ||
WGK 독일 | 3 | ||
RTECS 번호 | YV7120000 | ||
위험 등급 | IRRITANT | ||
HS 번호 | 2918992090 | ||
유해 물질 데이터 | 25812-30-0(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz) |
겜핍로질 C화학적 특성, 용도, 생산
개요
Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.화학적 성질
White Crystalline Powder용도
Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.World Health Organization (WHO)
Gemfibrozil, an antihyperlipidaemic derivative of clofibrate, was introduced in the early 1980's. It is registered in several countries for the treatment of hyperlipidaemia unresponsive to dietary measures. (See also the WHO comment for clofibrate).일반 설명
Gemfibrozil, 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Lopid), is a congener of clofibratethat was used first in the treatment of hyperlipoproteinemia inthe mid-1970s. Its mechanism of action and use are similar tothose of clofibrate. Gemfibrozil reduces plasma levels ofVLDL triglycerides and stimulates clearance of VLDL fromplasma. The drug has little effect on cholesterol plasma levelsbut does cause an increase of HDL.Gemfibrozil is absorbed quickly from the gut and excretedunchanged in the urine. The drug has a plasma half-life of1.5 hours, but reduction of plasma VLDL concentration takesbetween 2 and 5 days to become evident. The peak effect of its hypolipidemic action may take up to 4 weeks to becomemanifest.
Mechanism of action
From the chemical point of view, gemfibrozil is somewhat related to clofibrate and has analogous pharmacological use. The primary action of gemibrozil as well as clofibrate consists of a significant reduction in the level of very low-density proteins in the plasma and an increase in high-density protein formation.겜핍로질 준비 용품 및 원자재
원자재
수소화나트륨
Oil suspension
2,5-자일렌올
이소낙산
경 무기 기름
Sodium isobutyrate
다이아이소프로필아민
1,3-디브로모프로판
펜탄
다이메틸 설폭사이드
1-브로모프로판
라우랄코늄브로마이드
산화마그네슘
황산마그네슘
리튬
부틸리튬
CHLORANILIC ACID LANTHANUM SALT
3-(2,5-XYLYLOXY)PROPYL BROMIDE
준비 용품
겜핍로질 공급 업체
글로벌( 506)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 |
CHINA | 2783 | 58 | |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 |
admin@zhanyaobio.com | China | 2136 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |