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Florfenicol

Florfenicol 구조식 이미지
카스 번호:
73231-34-2
상품명:
Florfenicol
동의어(영문):
NUFLOR;AQUAFEN;Aquaflor;SCH-25298;FLUPROFEN;Florfeniol;lorfenicol;FLORFENICOL;Florfenicol-d2;Florfenicol>
CBNumber:
CB9195978
분자식:
C12H14Cl2FNO4S
포뮬러 무게:
358.21
MOL 파일:
73231-34-2.mol

Florfenicol 속성

녹는점
153 °C
끓는 점
618℃
알파
26 +17.9° (DMF)
밀도
1.451±0.06 g/cm3(Predicted)
RTECS 번호
DB6034000
인화점
>110°(230°F)
저장 조건
Inert atmosphere,2-8°C
용해도
Soluble in ethanol to 25mM and in DMSO to 100mM
물리적 상태
solid
산도 계수 (pKa)
10.73±0.46(Predicted)
Merck
14,4109
CAS 데이터베이스
73231-34-2(CAS DataBase Reference)
EPA
Florfenicol (73231-34-2)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 3
HS 번호 29419090

Florfenicol C화학적 특성, 용도, 생산

개요

Florfenicol 는 불 화 합성 수의학 에서 주로 사용 하는 thiamphenicol 의 아날로그. 에 존재 하는 백색 분말 또는 결정성 분말, 무 취, 녹는점: 153 ℃, 비등 점: 760 mmHg에서 617.5 ° C.

용도

분석 결과 항균 에이전트 돼지, 닭 및 물고기 민감한 박테리아, 특히 호흡기 감염 및 창 자 감염으로 인 한 세균성 질병.

포장, 보관 및 운송

계속 컨테이너 건조 하 고 통풍이 잘되는 장소에 단단히 마감 했다.

개요

Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol (Item No. 21357). It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC50s = 6.3-12.5 μg/ml). Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC50s = 0.25-4 μg/ml). It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM. Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.

화학적 성질

White Crystalline Powder

용도

Fluorinated derivative of thiamphenicol. Inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. An antibacterial

용도

Antibacterial;Protein synthesis inhibitor

용도

Florfenicol is a fluorinated derivative of thiamphenicol. Florfenicol inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial.

용도

Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Florfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations.

정의

ChEBI: A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respirat ry disease and foot rot; also used in aquaculture.

Veterinary Drugs and Treatments

The drug is approved for use in cattle only (in the USA) for the treatment of bovine respiratory disease (BRD) associated with Pasteurella haemolytica, Pasteurella multocida, and Haemophilus somnus.
Because florfenicol has activity against a wide range of microorganisms (e.g., Mycoplasma), it may be useful for treating other infections in cattle (or other species) as well, but specific data is limited.

Florfenicol 준비 용품 및 원자재

원자재

준비 용품


Florfenicol 공급 업체

글로벌( 440)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Masteam Bio-tech Co., Ltd.
86-15897918789 86-15200345168
bruce.lei@masteam.com CHINA 153 58
Hebei Henghe Import and Export Trading Co. LTD
18032916000 +8618032935937
demi@hbtycoon.com CHINA 453 58
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
86-27-59524646 info@fortunachem.com CHINA 3073 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9115 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

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