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염화아세틸콜린

염화아세틸콜린
염화아세틸콜린 구조식 이미지
카스 번호:
60-31-1
한글명:
염화아세틸콜린
동의어(한글):
염화아세틸콜린;아세틸콜린클로라이드
상품명:
Acetylcholine chloride
동의어(영문):
ACH;ovisot;tl1505;miochol;acecholin;ACECOLINE;achchloride;arterocoline;ARTEROCHOLINE;Acetylcholine chlori
CBNumber:
CB9216208
분자식:
C7H16ClNO2
포뮬러 무게:
181.66
MOL 파일:
60-31-1.mol

염화아세틸콜린 속성

녹는점
146-150 °C(lit.)
밀도
1.1235 (rough estimate)
굴절률
1.5560 (estimate)
저장 조건
0-6°C
용해도
H2O: 0.1 g/mL, clear, colorless
물리적 상태
Crystalline Powder
색상
White
수용성
Soluble IN COLD WATER
감도
Hygroscopic
Merck
14,87
BRN
3571875
안정성
Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.
CAS 데이터베이스
60-31-1(CAS DataBase Reference)
EPA
Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride(60-31-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-37/39-36
WGK 독일 2
RTECS 번호 FZ9800000
F 고인화성물질 3-8-10-21
TSCA Yes
위험 등급 IRRITANT
HS 번호 29379000
독성 LD50 in mice, rats (mg/kg): 20, 22 i.v., 170, 250 s.c., 3000, 2500 i.p. (Molitor)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

염화아세틸콜린 C화학적 특성, 용도, 생산

화학적 성질

White or almost white crystalline powder or colourless crystals, very hygroscopic.

용도

Acetylcholine Chloride is a cholinergic.

용도

cholinergic, antiarrhythmic, miotic, vasodilator (peripheral)

용도

endogenous neurotransmitter at cholinergic synapses; amplifies sarcolemma action potential inducing muscle contractions

용도

A cholinergic neurotransmitter that can induce the opening of calcium channels

정의

ChEBI: The chloride salt of acetylcholine, and a parasympatomimetic drug.

상표명

Miochol (Novartis).

일반 설명

ACh chloride exerts a powerfulstimulant effect on the parasympathetic nervous system.Attempts have been made to use it as a cholinergic agent,but its duration of action is too short for sustained effects,because of rapid hydrolysis by esterases and lack of specificitywhen administered for systemic effects. It is a cardiacdepressant and an effective vasodilator. Stimulation of thevagus and the parasympathetic nervous system produces atonic action on smooth muscle and induces a flow from thesalivary and lacrimal glands. Its cardiac-depressant effectresults from (a) a negative chronotropic effect that causes adecrease in heart rate and (b) a negative inotropic action onheart muscle that produces a decrease in the force of myocardialcontractions.

생물학적 활성

Endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

Clinical Use

Atropine blocks the depressant effect of ACh on cardiacmuscle and its production of peripheral vasodilation (i.e.,muscarinic effects) but does not affect the skeletal musclecontraction (i.e., nicotinic effect) produced.ACh chloride is a hygroscopic powder that is available inan admixture with mannitol to be dissolved in sterile waterfor injection shortly before use. It is a short-acting mioticwhen introduced into the anterior chamber of the eye and isespecially useful after cataract surgery during the placementof sutures. When applied topically to the eye, it has littletherapeutic value because of poor corneal penetration andrapid hydrolysis by AChE.

Safety Profile

Poison by subcutaneous, intravenous, and parenteral routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. A cholinergic agent. See also CHOLINE ACETATE (ESTER).

Purification Methods

It is very soluble in H2O (>10%), and is very hygroscopic. If pasty, dry it in a vacuum desiccator over H2SO4 until a solid residue is obtained. Dissolve this in absolute EtOH, filter it and add dry Et2O, when the hydrochloride separates. Collect by filtration and store it under very dry conditions. [Jones & Major J Am Chem Soc 52 307 1930.] The chloroplatinate crystallises from hot H2O in yellow needles and can be recrystallised from 50% EtOH, m 242-244o [Dudley Biochem J 23 1069 1929]; other m given is 256-257o. The perchlorate crystallises from EtOH as prisms m 116-117o. [J Am Pharm Assocn 36 272 1947, Beilstein 4 IV 1446.]

염화아세틸콜린 준비 용품 및 원자재

원자재

준비 용품


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