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Hygrolidin

Hygrolidin 구조식 이미지

카스 번호:: 83329-73-1

상품명:: Hygrolidin

동의어(영문):: 1166C;Hygrolidin;Antibiotic 1166C;2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)

CBNumber:: CB92219966

분자식:: C38H58O11

포뮬러 무게:: 690.86

MOL 파일:: 83329-73-1.mol

속성

안전

용도

공급 업체 24

Hygrolidin 속성

끓는 점: 821.1±65.0 °C(Predicted)

밀도: 1.17±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

물리적 상태: 고체

산도 계수 (pKa): 3.28±0.10(Predicted)

안전

HS 번호	29419000

Hygrolidin C화학적 특성, 용도, 생산

개요

Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC₅₀s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G₁ and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC₅₀s = 1.1, 72.5, 77, and 24.5 nM, respectively).

용도

Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumour cells, and inhibits the growth of solid tumour-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels. Hygrolidin-induced p21 inhibits cyclin A-cdk2 complex more strongly than cyclin E-cdk2 complex. It also increases p21 mRNA in DLD-1 cells, but not in normal fibroblasts.

Hygrolidin 준비 용품 및 원자재

원자재

준비 용품

Hygrolidin 공급 업체

글로벌( 24)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55717	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Meng Cheng Technology (Shanghai) Co., LTD	400-820-6829	sales@mitachieve.com	China	8864	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3661	58