6-Aminopyridine-3-carboxamide

6-Aminopyridine-3-carboxamide 구조식 이미지
카스 번호:
329-89-5
상품명:
6-Aminopyridine-3-carboxamide
동의어(영문):
6-AN;6-ANA;U-8774;fda0121;SR-4388;FDA 0121;nsc21206;NSC 21206;NSC-13128;BRN 2034522
CBNumber:
CB9224555
분자식:
C6H7N3O
포뮬러 무게:
137.14
MOL 파일:
329-89-5.mol
MSDS 파일:
SDS

6-Aminopyridine-3-carboxamide 속성

녹는점
245-248 °C (lit.)
끓는 점
251.97°C (rough estimate)
밀도
1.2620 (rough estimate)
굴절률
1.6910 (estimate)
저장 조건
Keep in dark place,Inert atmosphere,Room temperature
용해도
insoluble in H2O; insoluble in EtOH; ≥13.7 mg/mL in DMSO
물리적 상태
powder to crystal
산도 계수 (pKa)
15.66±0.50(Predicted)
색상
흰색에서 밝은 노란색
수용성
디메틸설폭사이드(DMSO)에 용해됩니다. 물에 불용성.
BRN
116042
CAS 데이터베이스
329-89-5(CAS DataBase Reference)
NIST
Nicotinamide, 6-amino-(329-89-5)
EPA
6-Aminonicotinamide (329-89-5)
안전
  • 위험 및 안전 성명
위험품 표기 T
위험 카페고리 넘버 61
안전지침서 53-45
유엔번호(UN No.) 1655
WGK 독일 3
RTECS 번호 US4550000
위험 참고 사항 Toxic
위험 등급 6.1
포장분류 II
HS 번호 29333990
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
NFPA 704
1
3 0

6-Aminopyridine-3-carboxamide C화학적 특성, 용도, 생산

용도

antineoplastic, apoptosis inducer

정의

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.

일반 설명

White crystalline solid.

공기와 물의 반응

Insoluble in water.

반응 프로필

An amine and amide. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

건강위험

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-Aminopyridine-3-carboxamide emits toxic fumes of NOx.

화재위험

Flash point data for 6-Aminopyridine-3-carboxamide are not available; however, 6-Aminopyridine-3-carboxamide is probably combustible.

6-Aminopyridine-3-carboxamide 준비 용품 및 원자재

원자재

준비 용품


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