Borane-tetrahydrofuran complex
|
|
Borane-tetrahydrofuran complex 속성
- 녹는점
- -17 °C
- 끓는 점
- 35 °C
- 밀도
- 0.898 g/mL at 25 °C
- 인화점
- 1 °F
- 저장 조건
- Store at <= 20°C.
- 물리적 상태
- 액체
- 색상
- 무색의
- 수용성
- 물과 반응
- 감도
- Air & Moisture Sensitive
- BRN
- 3668402
- 노출 한도
- ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
- 안정성
- 안정적이지만 공기와 접촉하면 폭발성 과산화물을 형성할 수 있습니다. 산, 산 염화물, 산 무수물, 산화제, 알코올과 호환되지 않습니다. 물과 격렬하게 반응함. 가연성이 높습니다. 불활성 가스하에 보관하십시오.
- CAS 데이터베이스
- 14044-65-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 14/15-19-22-36/37/38-41-37/38-11-67-66-40-36/37 | ||
안전지침서 | 16-33-36/37/39-7/9-7/8-43-37/39-26-36-29-36/37 | ||
유엔번호(UN No.) | UN 3399 4.3/PG 1 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 1-10-13-34 | ||
TSCA | Yes | ||
위험 등급 | 4.3 | ||
포장분류 | I | ||
HS 번호 | 29321900 |
Borane-tetrahydrofuran complex C화학적 특성, 용도, 생산
개요
Borane tetrahydrofuran complex (BH3-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.It is a charge-transfer complex that is a useful surrogate for diborane1 in organic synthesis. It can be used to reduce carboxylic acids to alcohols or nitriles to primary amines. It reacts with olefins to add the BH2 functional group. Alkyl- or arylboranes formed in this way can further react with unsaturated compounds such as olefins, imines, ketones, and alkynes (the hydroboration reaction) to make useful boron-containing intermediates.화학적 성질
colourless liquid용도
Borane-tetrahydrofuran complex is used to reduce Nylon surface amide groups to secondary amines.It is an important reagent used in the reduction of certain functional groups viz. aldehyde, ketone, carboxylic acid, amide, oxime, imine and nitrile. It is also used as hydro borating agent. It acts as a borane source for oxazaborolidine catalyzed asymmetric reductions.주요 응용
New, Safer, NIMBA-Stabilized BH3 THF SolutionsBH3-THF can be used as a reducing agent for the reduction of various functional groups such as carboxylic acids, aldehydes, ketones, esters, acid chlorides, nitriles, epoxides, amides, lactones, oximes, and imines into corresponding alcohols and amines. Grignard reagents, arylmercury, arylthalium, and allyl and propargyllithium compounds react with BH3?THF to give organoboranes, which can be oxidized to the corresponding alcohols, phenols, and 1,3-diols.
It can also be used:
To synthesize the chiral borane catalyst, which is used in the enantioselective halo-aldol reaction.
To prepare 9-unsubstituted acridines by reduction of corresponding acridones.
To reduce nylon surface amide groups to secondary amines.
화학 반응
Borane-tetrahydrofuran complex (BTHF) is a valuable reagent for the reduction of functional groups and for hydroboration reactions with carbon-carbon double and triple bonds. Functional groups that are readily reduced by BTHF include aldehyde, ketone, carboxylic acid, amide, oxime, imine, and nitrile. The carboxylic acid group is reduced at a faster rate than most groups including non-conjugated alkene. Conjugated α,β-unsaturated carboxylic acids give saturated alcohols as the major products.Ketones and the carbonyl of enones are effectively reduced with borane-tetrahydrofuran. The addition of borohydride to the reaction solution is advantageous for accelerated reduction as well as higher selectivity towards carbonyl reduction in conjugated and non-conjugated enones.
Asymmetric ketone reduction using chiral oxazaborolidine catalysts was recently reviewed. Work at Callery with BTHF improved on reaction conditions to provide consistent results in the reduction.
일반 설명
Borane tetrahydrofuran complex (BH3-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.주의 사항
Air and moisture sensitive. Forms explosive peroxides in contact with air. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents and alcohols. On hydrolysis, it forms hydrogen and boric acid.Borane-tetrahydrofuran complex 준비 용품 및 원자재
원자재
준비 용품
6-bromo-1,2,3,4-tetrahydroisoquinoline
CATECHOLBORANE
1-(4-Morpholinobutyl)hydrazine
1-Methyl-3-phenylpiperazine
1-(3-(pyrrolidin-1-yl)propyl)hydrazine
1-(4-(Pyrrolidin-1-yl)butyl)hydrazine
1,1,2-Trimethylpropylborane
BORANE-DIISOPROPYLAMINE
Dicyclohexylborane
Borane - 5-Ethyl-2-Methylpyridine CoMplex
Trimethoxyboroxine
9-BBN DIMER
1-Octylboronic acid
METHYLDIPHENYLPHOSPHINE
BORANE-N,N-DIETHYLANILINE COMPLEX
Borane-triethylamine complex
Borane-tetrahydrofuran complex 공급 업체
글로벌( 287)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15371 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2966 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
Richest Group Ltd | 18017061086 |
oled@richest-group.com | CHINA | 5601 | 58 |
Borane-tetrahydrofuran complex 관련 검색:
테트라하이드로푸란 나트륨 붕소수화물 아르곤 황화디메틸 피리딘보란 부가물 트리에틸보란 디메틸설파이드보란 트리메시틸보란 붕소
INTERMEDIATES
BORANE - 2-PICOLINE COMPLEX
1,2,3,4-Tetrahydronaphthalene
TETRAETHYLSILANE
ENDO-TETRAHYDRODICYCLOPENTADIENE
2-Tetrahydrofuroic acid
Boron trifluoride tetrahydrofuran complex
Diethyl mathoxy borane
N,N-Diisopropylethylamine borane