o-클로로톨루엔
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o-클로로톨루엔 속성
- 녹는점
- -36 °C (lit.)
- 끓는 점
- 157-159 °C (lit.)
- 밀도
- 1.083 g/mL at 25 °C (lit.)
- 증기 밀도
- 4.38 (vs air)
- 증기압
- 10 mm Hg ( 43 °C)
- 굴절률
- n
20/D 1.525(lit.)
- 인화점
- 117 °F
- 저장 조건
- 0-6°C
- 용해도
- H2O: 20°C에서 난용성0.047g/L
- 물리적 상태
- 액체
- 색상
- 투명한
- 폭발한계
- 1.0-12.6%(V)
- 수용성
- 약간 용해됨
- Merck
- 14,2171
- BRN
- 1904175
- Dielectric constant
- 4.4500000000000002
- 노출 한도
- ACGIH: TWA 50 ppm
NIOSH: TWA 50 ppm(250 mg/m3); STEL 75 ppm(375 mg/m3)
- InChIKey
- IBSQPLPBRSHTTG-UHFFFAOYSA-N
- LogP
- 3.42 at 25℃
- CAS 데이터베이스
- 95-49-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,N,F,Xi,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20-51/53-39/23/24/25-23/24/25-11 | ||
| 안전지침서 | 24/25-61-45-36/37-16-7 | ||
| 유엔번호(UN No.) | UN 2238 3/PG 3 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | XS9000000 | ||
| 자연 발화 온도 | 600°C | ||
| 위험 참고 사항 | Irritant/Flammable | ||
| TSCA | Yes | ||
| 위험 등급 | 3 | ||
| 포장분류 | III | ||
| HS 번호 | 29036990 | ||
| 유해 물질 데이터 | 95-49-8(Hazardous Substances Data) | ||
| 기존화학 물질 | KE-05915 |
o-클로로톨루엔 C화학적 특성, 용도, 생산
개요
2-Chlorotoluene can be mineralized completely by Rhodococcus, strain OCT 10 DSM 45596(T). It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol. The oxidation of 2-chlorotoluene is very well catalyzed by the enzymes: toluene dioxygenase of P. putida F1 and chlorobenzene dioxygenase from Burkholderia, strain PS12.화학적 성질
o-Chlorotoluene is a flammable, colorless liquid with an aromatic odor.용도
Solvent and intermediate for organic chemicals and dyes.2-Chlorotoluene is used for permanganate oxidation to give o-chlorobenzoic acid. It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol.
2-Chlorotoluene can be used as a precursor to synthesize aryl coupling products via palladium-catalyzed Negishi cross-coupling. It can also be used in the Buchwald-Hartwig amination to synthesize arylamines.
제조 방법
The solution of cuprous chloride is cooled in an ice bath 0-5° C temperature. In this cold solution, the 2-methylbenzenediazonium is poured with constant shaking and allowing the mixture to come to room temperature. After about 10 minutes, the mixture gradually warmed with a good shaking.As the temperature rises the brown addition product begins to decompose with the evolution of nitrogen and with the formation of an oily layer of 2-chlorotoluene. When the decomposition reaction is at an end, the mixture is steam distilled, continuing the process only as long as oily droplets are present in the distillate, for the product is not appreciably soluble in water. The layer of 2-chlorotoluene is carefully separated and washed twice with an equal volume of concentrated sulfuric acid, which removes both the 2-cresol and the azo compound. Then 2-chlorotoluene is washed with water in order to remove the inorganic acid. Finally, 2-chlorotoluene is dried over calcium chloride, distilled, using an air condenser and collecting the product boiling at 153-158° C. Pure 2-chlorotoluene boils at 157° C. The yield is 25-30 g.
Experiments in Organic Chemistry, L. F. Fieser, 216, 1941
Highly Selective Oxidative Monochlorination To Synthesize Organic Intermediates: 2-Chlorotoluene, 2-Chloroaniline, 2-Chlorophenol, and 2-Chloro-4-methylphenol
일반 설명
Colorless liquid with an aromatic odor. Denser than water and poorly soluble in water. Hence sinks in water .공기와 물의 반응
Slightly water soluble.반응 프로필
2-Chlorotoluene may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Reacts violently with dimethyl sulfoxide .위험도
Toxic by inhalation. Eye, skin, and upper respiratory tract irritant.건강위험
Inhalation of vapor may cause respiratory irrtation. Prolonged and repeated vapor exposures may produce systemic toxic effects.Safety Profile
Moderately toxic by unspecified routes. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLE CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.잠재적 노출
o-Chlorotoluene is widely used as a solvent and intermediate in the synthesis of dyes, synthetic rubber; pharmaceuticals; and other organic chemicals. Used as an insecticide, bactericide.운송 방법
UN2238 Chlorotoluenes, Hazard Class: 3; Labels: 3-Flammable liquid.Purification Methods
Dry 2-chlorotoluene for several days with CaCl2, then distil it from Na using a glass helices-packed column. [Beilstein 5 IV 805.]비 호환성
Incompatible with acids, alkalis, oxidizers, reducing materials; water폐기물 처리
In accordance with 40CFR165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.o-클로로톨루엔 준비 용품 및 원자재
원자재
준비 용품
o-클로로벤조트리플루오라이드
o-클로로벤조트리클로라이드
2,4-디클로로톨루엔
Chlorphoxim
2-클로로페닐 초산
디클로페낙 나트륨
o-클로로벤질클로라이드
2-클로로벤조익산
클로트라이마졸
2-Chlorobenzyl bromide
3-CHLOROBENZAL CHLORIDE
o-클로로벤즈알데히드
p-클로로톨루엔
2-(Dicyclohexylphosphino)-2'-methylbiphenyl
2,2'-DIMETHYLBIPHENYL
Benzeneethanamine, 2-chloro-α-phenyl-
5-BROMO-2-CHLOROTOLUENE
o-클로로톨루엔 공급 업체
글로벌( 382)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Ningxia Jinhua Chemical Co.,Ltd | 025-52279164 |
info@nxjhchem.com | China | 79 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9165 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7613 | 58 |
| Shanghai Xin Cheng Yue Chemical Co.,Ltd | +86-021-57806787 +86-17701820076 |
wuziwei@xinyuefirm.com | China | 30 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |