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2-chloro-5-methylpyridin-4-amine

2-chloro-5-methylpyridin-4-amine 구조식 이미지

카스 번호:: 79055-62-2

상품명:: 2-chloro-5-methylpyridin-4-amine

동의어(영문):: 2-Chloro-5-Methyl-pyridin-4-ylaMine;Fampridine Impurity 174;2-chloro-5-methylpyridin-4-amine;2-Chloro-5-Methyl-4-pyridinaMine;2-Chloro-4-amino-5-methylpyridine;4-aMino-2-chloro-5-Methylpyridine;2-Chloro-5-methyl pyridine-4-amine;4-PYRIDINAMINE, 2-CHLORO-5-METHYL-;2-Chloro-5-methylpyridin-4-amine98%;2-Chloro-5-methylpyridin-4-amine 98%

CBNumber:: CB92468371

분자식:: C6H7ClN2

포뮬러 무게:: 142.59

MOL 파일:: 79055-62-2.mol

속성

안전

용도

공급 업체 223

2-chloro-5-methylpyridin-4-amine 속성

녹는점: 115℃

끓는 점: 310.1±37.0 °C(Predicted)

밀도: 1.260±0.06 g/cm3(Predicted)

저장 조건: under inert gas (nitrogen or Argon) at 2–8 °C

물리적 상태: 가루

산도 계수 (pKa): 5.11±0.42(Predicted)

색상: 회백색

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2933399990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P260	분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

2-chloro-5-methylpyridin-4-amine C화학적 특성, 용도, 생산

Synthesis

2-chloro-5-methylpyridin-4-amine was synthesised by reaction with 2-chloro-5-methyl-4-nitropyridine 1-oxide. The synthesis steps are as follows:
A glass pressure reactor with cross-beam stirrer was charged under argon with 29 g (153.788 mmol) of 2-chloro-5-methyl-4-nitro-1-oxidopyridin-1-ium and 2.9 g of hydrogenation catalyst (0.8% Pt and 0.6% Mo on activated carbon (D505A-105 0.8% Pt+0.6% Mo on carbon powder, BASF) and 320 ml of ethanol were added. The reactor was closed and inertized three times, each time with 3 bar argon overpressure. Hydrogenation was then carried out for 20 hours at 30℃, under a 3 bar hydrogen overpressure (conversion >98%). The reactor was inertized with argon and the reaction solution filtered through 10 g of kieselguhr. The filtrate was concentrated to dryness under reduced pressure. Yield: 23.0 g (quantitative, product still contained ethanol), purity: 97.5% (HPLC) (0051) MS (EIpos): m/z=143 [M+H]+ (0052) 1H-NMR (300 MHz, DMSO-d6): δ=1.96 (s, 3H), 6.16 (br s, 2H), 6.50 (s, 1H), 7.68 (s, 1H) In an analogous manner, a conversion of approx. 98% was achieved with a catalyst consisting of 0.8% Pt and 0.3% Mo on activated carbon. Use of 1% Pt+2% V on activated carbon achieved a conversion of approx. 87%.

2-chloro-5-methylpyridin-4-amine 준비 용품 및 원자재

원자재

2-CHLORO-5-METHYL-4-NITROPYRIDINE-N-OXIDE PYRIDINE, 2-CHLORO-5-METHYL-, 1-OXIDE 2-Chloro-5-methylpyridine

준비 용품

4-AMino-5-Methylpyridin-2-ol

2-chloro-5-methylpyridin-4-amine 공급 업체

글로벌( 223)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
ZHEJIANG CHEMPACIFIC CHEMICAL CO.,LTD	+86-13586356488 13586348435	sales@chempacific.com	CHINA	88	58

2-chloro-5-methylpyridin-4-amine 관련 검색:

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE