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WYE-354

WYE-354 구조식 이미지

카스 번호:: 1062169-56-5

상품명:: WYE-354

동의어(영문):: CS-441;WYE-354;Wye354 Wye-354;WYE-354 USP/EP/BP;WYE-354 (Degrasyn);WYE-354;WYE 354; WYE354;mTOR Kinase Inhibitor II WYE-354 WYE354;Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;Methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

CBNumber:: CB92512520

분자식:: C24H29N7O5

포뮬러 무게:: 495.53

MOL 파일:: 1062169-56-5.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 92

WYE-354 속성

밀도: 1.46

저장 조건: Sealed in dry,Store in freezer, under -20°C

용해도: ≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 13.42±0.70(Predicted)

안전

WYE-354 C화학적 특성, 용도, 생산

개요

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC₅₀ = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC₅₀ = 1,026 nM) and other kinases. WYE-354 induces G₁ cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.

용도

A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

WYE-354 준비 용품 및 원자재

원자재

준비 용품

WYE-354 공급 업체

글로벌( 92)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29321	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

WYE-354 관련 검색:

WYE 354-d3 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE-687 Selumetinib U0126-EtOH MK-2206 2HCl 1,9-Pyrazoloanthrone KU-0063794 BEZ235 (NVP-BEZ235, Dactolisib)