N-[3-[[(2-히드록시-1-나프탈레닐)메틸렌]아미노]페닐]-α-메틸벤젠아세트아미드 C화학적 특성, 용도, 생산
개요
The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~20 μM) by reactivating proapototic genes that are repressed by SIRT1.
용도
Salermide is an inhibitor of SIRT1, SIRT2, and HDAC.
일반 설명
A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 μM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 and 566321), at 100 μM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 μM) in killing leukemia KG1A and lymphoma Raji cultures.
N-[3-[[(2-히드록시-1-나프탈레닐)메틸렌]아미노]페닐]-α-메틸벤젠아세트아미드 준비 용품 및 원자재
원자재
준비 용품
N-[3-[[(2-히드록시-1-나프탈레닐)메틸렌]아미노]페닐]-α-메틸벤젠아세트아미드 공급 업체