ChemicalBook >제품 카탈로그 >유기 화학>유기 불소 화합물>Fluoro-benzoic acid series>2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 구조식 이미지

카스 번호:: 763114-26-7

상품명:: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

동의어(영문):: EOS-61877;Olapali impurity 25;Olaparib Intermediate 1;Olaparib intermediate 763114-26-7;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...

CBNumber:: CB92554162

분자식:: C16H11FN2O3

포뮬러 무게:: 298.27

MOL 파일:: 763114-26-7.mol

속성

안전

용도

공급 업체 285

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 속성

밀도: 1.42

저장 조건: Sealed in dry,Room Temperature

산도 계수 (pKa): 3.19±0.10(Predicted)

물리적 상태: 가루

색상: 흰색에서 황백색까지

InChI: InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)

InChIKey: PAXLJNGPFJEKQX-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=CC(CC2C3=C(C=CC=C3)C(=O)NN=2)=CC=C1F

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2916399090

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P280

보호장갑/보호의/보안경/안면보호구를 착용하시오.

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid C화학적 특성, 용도, 생산

용도

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.

주요 응용

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.

Synthesis

Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 준비 용품 및 원자재

원자재

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-FLUORO-5-FORMYLBENZOIC ACID 95 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile 2-Carboxybenzaldehyde

준비 용품

Fluzoparib AZD2461

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 공급 업체

글로벌( 285)공급 업체

공급자	전화	이메일	국가	제품 수	이점
PharmOrgSyn Laboratories Co., Ltd.	+86-021-38228826 +86-13916602830	sales@pharmorgsyn.cn	China	140	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091 +86-18616643091	info@rochipharma.com	China	246	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 관련 검색:

2-메틸-2,4-펜타네다이올 Cyclopentanone 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid Olaparib CIS-BICYCLO[3.3.0]OCTANE-3,7-DIONE TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile Veliparib Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Olaparib Impurity 12 Olaparib Impurity 29 Olaparib Impurity 32 Olaparib Impurity 27 Olaparib Impurity 21 Olaparib Impurity 23 Olaparib Impurity 24 Olaparib Impurity 28