코르티손-21-아세트산
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코르티손-21-아세트산 속성
- 녹는점
- 237-240 °C(lit.)
- 끓는 점
- 577.3±50.0 °C(Predicted)
- 알파
- D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
- 밀도
- 1.26±0.1 g/cm3(Predicted)
- 굴절률
- 212 ° (C=1, MeOH)
- 저장 조건
- 2-8°C
- 용해도
- 물에 거의 녹지 않으며, 염화메틸렌에 잘 녹고, 디옥산에 녹고, 아세톤에는 조금 녹고, 에탄올(96%)과 메탄올에는 약간 녹습니다.
- 산도 계수 (pKa)
- 12.32±0.60(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 19mg/L(25℃)
- Merck
- 14,2539
- BRN
- 2067543
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- CAS 데이터베이스
- 50-04-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 22-36/37-24/25 | ||
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WGK 독일 | 3 | ||
RTECS 번호 | GM9140000 | ||
HS 번호 | 32041200 |
코르티손-21-아세트산 C화학적 특성, 용도, 생산
개요
Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.화학적 성질
White needle crystal or crystalline powder (acetone), odorless. Stable in the air. Mp239- 241°C, specific rotation [α]20D+164°(0.5%, acetone), [α]23D+169°(chloroform), [α]25D+208°-+217°(dioxane), The ethanol solution of this product has a maximum absorption at a wavelength of 240nm. Soluble in chloroform (1:4), soluble in acetone (1:75), slightly soluble in ethanol and ether, and hardly soluble in water. This product dissolves in sulfuric acid and turns yellow without fluorescence (different from hydrocortisone acetate).용도
Cortisone Acetate (Hydrocortisone Acetate EP Impurity D) is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone.제조 방법
Cortisone acetate is prepared from dehydropregnenolone by epoxidation, Wolff's oxidation, mycoxidation, chromic acid oxidation, hydrogen bromide ring-opening, Raney's nickel-catalyzed debromination, iodination, and acetyloxy substitution.일반 설명
Cortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.Purification Methods
Crystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]참고 문헌
1. Cortisone acetate in skin disease; local effect in the skin from topical application and local injection. DOI:10.1001/ARCHDERM.1952.015302100560072. McCue, R.E., Dannenberg, A.M., Jr., Huguchi, S., et al. The effect of cortisone on the accumulation, activation, and necrosis of macrophages in tuberculous lesions. Inflammation 3(2), 159-176 (1978). DOI:10.1007/BF00910737
3. Joseph, J., and Tydd, M. The effects of cortisone acetate on tissue regeneration in the rabbit’s ear. J. Anat. 115(Pt. 3), 445-460 (1973).
4. Schlechte, J.A., Ginsberg, B.H., and Sherman, B.M. Regulation of the glucocorticoid receptor in human lymphocytes. J. Steroid Biochem. 16(1), 69-74 (1982). DOI:10.1016/0022-4731(82)90145-5
5. Sittig's Pharmaceutical Manufacturing Encyclopedia
6. Textbook of organic medicinal and pharmaceutical chemistry. DOI:10.1002/jps.3030451120
7. Purification of Laboratory Chemicals DOI:10.5860/choice.50-6768
코르티손-21-아세트산 준비 용품 및 원자재
원자재
16-Dehydropregnenolone
과산화 수소
니켈
삼산화크롬무수물
크롬(6+) 트리산화물
16-Dehydropregnenolone acetate
코르티존
16a,17a-Epoxyprogesterone
아세트산 칼륨
사포닌
사이안화 칼륨
아세트산(빙초산)
오스뮴산
Pregn-5-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal)
Pregn-4-ene-3,11,20-trione, 9-bromo-17,21-dihydroxy-, 21-acetate
Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-
9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
Anecortave Acetate
준비 용품
코르티손-21-아세트산 공급 업체
글로벌( 356)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Kangcang new material Technology Co., LTD | +8619133911216 |
fanfan@kangcang.com.cn | China | 340 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 893 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 |
sales@czwytech.com | CHINA | 906 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
코르티손-21-아세트산 관련 검색:
아세트산 셀룰로스 초산비닐모노머 초산에틸 아세트산 나트륨 폴리초산비닐 히드로코르티손 히드로코르티손 아세트산 아세트산 암모늄 코르티존 코르티손-21-아세트산
Glatiramer acetate
ACETATE
21-DEOXYCORTISONE
CORTISONE ACETATE DIETHYLENEKETAL
CORTISONE-21-ACETATE (CORTISONE ACETATE)
Cortisone Acetate, Powder
CORTISONE ACETATE USP 23
CORTISONE ACETATE IMP. A (EP): HYDROCORTISONE ACETATE