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코르티손-21-아세트산

코르티손-21-아세트산
코르티손-21-아세트산 구조식 이미지
카스 번호:
50-04-4
한글명:
코르티손-21-아세트산
동의어(한글):
코르티손아세테이트;코르티손-21-아세트산;코르티손
상품명:
Cortisone acetate
동의어(영문):
artriona;cortelan;cortisyl;ricortex;NSC 49420;cortistab;biocortacetate;cortoneacetate;irisoneacetate;cortogenacetate
CBNumber:
CB9277612
분자식:
C23H30O6
포뮬러 무게:
402.48
MOL 파일:
50-04-4.mol

코르티손-21-아세트산 속성

녹는점
237-240 °C(lit.)
알파
D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
굴절률
212 ° (C=1, MeOH)
저장 조건
2-8°C
용해도
Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
물리적 상태
neat
Merck
14,2539
BRN
2067543
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
50-04-4(CAS DataBase Reference)
EPA
Pregn-4-ene-3,11, 20-trione, 21-(acetyloxy)-17-hydroxy- (50-04-4)

안전

안전지침서 22-36/37-24/25
WGK 독일 3
RTECS 번호 GM9140000
HS 번호 32041200

코르티손-21-아세트산 C화학적 특성, 용도, 생산

화학적 성질

solid

용도

Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).

일반 설명

Cortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.

Purification Methods

Crystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]

코르티손-21-아세트산 준비 용품 및 원자재

원자재

준비 용품


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