4-PHENOXYPHENYLBORONIC ACID
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4-PHENOXYPHENYLBORONIC ACID 속성
- 녹는점
- 141-145 °C(lit.)
- 끓는 점
- 377.0±44.0 °C(Predicted)
- 밀도
- 1.23±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 메탄올에 용해됨
- 산도 계수 (pKa)
- 8.76±0.10(Predicted)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 베이지색
- InChI
- InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
- InChIKey
- KFXUHRXGLWUOJT-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
- CAS 데이터베이스
- 51067-38-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
4-PHENOXYPHENYLBORONIC ACID C화학적 특성, 용도, 생산
화학적 성질
white to off-white powder and chunk용도
4-Phenoxyphenylboronic acid can be used as a reactant:- In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
- To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
- To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.
Synthesis
4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).4-PHENOXYPHENYLBORONIC ACID 준비 용품 및 원자재
원자재
준비 용품
4-PHENOXYPHENYLBORONIC ACID 공급 업체
글로벌( 384)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 |
wangxuhui1985@126.com | China | 57 | 55 |
Hebei Maison Chemical Co.,Ltd. | +8615511852758 |
sales@maisonchem.com.cn | China | 484 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9287 | 55 |
4-PHENOXYPHENYLBORONIC ACID 관련 검색:
4-PHENOXYBENZOIC ACID
(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
4''-PROPYL-3-FLUOROBIPHENYL-4-BORONIC ACID
3,4,5-Trifluorophenylboronic acid
4-Chloro-2-fluoro-3-methoxyphenylboronic acid
4-(Hydroxymethyl)phenylboronic acid
3-Carboxyphenylboronic acid
3-Tolylboronic acid
1-Methyl-4-pyrazole boronic acid pinacol ester
Ibrutinib Impurity 24
Ibrutinib
(S)-Ibrutinib
(S)-3-Hydroxypiperidine
Ibrutinib Dimer Impurity
Ibrutinib Impurity 28
Ibrutinib Impurity 25
Acrylic anhydride
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine