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비닐피로리돈/비닐 아세트산 공중합체

비닐피로리돈/비닐 아세트산 공중합체
비닐피로리돈/비닐 아세트산 공중합체 구조식 이미지
카스 번호:
비닐피로리돈/비닐 아세트산 공중합체
Poly(1-vinylpyrrolidone-co-vinyl acetate)
포뮬러 무게:
MOL 파일:

비닐피로리돈/비닐 아세트산 공중합체 속성

1.27 g/mL at 25 °C(lit.)
1.4300 to 1.4380
72 °F
Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
물리적 상태
Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi,F
위험 카페고리 넘버 10-36/37/38-67-36-11-22
안전지침서 22-24/25-36/37/39-26-16
유엔번호(UN No.) UN 1987 3/PG 2
WGK 독일 1
RTECS 번호 AH3539000
위험 등급 3
포장분류 II
HS 번호 29349990
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H336 졸음 또는 현기증을 일으킬 수 있음 특정표적장기 독성 물질(1회 노출);마취작용 구분 3 경고 P261, P271, P304+P340, P312,P403+P233, P405, P501
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

비닐피로리돈/비닐 아세트산 공중합체 C화학적 특성, 용도, 생산

화학적 성질

white powder

화학적 성질

Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.


Poly(1-vinylpyrrolidone-co-vinyl acetate)

생산 방법

Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.

Pharmaceutical Applications

Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.


Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD50 (rat, oral): >0.63 g/kg


Copovidone is stable and should be stored in a well-closed container in a cool, dry place.

비 호환성

Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.

Regulatory Status

Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).

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글로벌( 137)공급 업체
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Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1878 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21686 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22633 55
career henan chemical co
+86-371-86658258 CHINA 29996 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23981 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 8814 58
Hebei Guanlang Biotechnology Co., Ltd.
whatsapp: +8619930501651 CHINA 2372 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6372 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23049 58

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