비닐피로리돈/비닐 아세트산 공중합체
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비닐피로리돈/비닐 아세트산 공중합체 속성
- 밀도
- 1.27 g/mL at 25 °C(lit.)
- 굴절률
- 1.4300 to 1.4380
- 인화점
- 72 °F
- 용해도
- Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
- 물리적 상태
- 가루
- 색상
- 하얀색
- 안정성
- 안정적인. 특히 분말 형태에서는 가연성입니다. 강한 산화제, 강한 환원제와 호환되지 않습니다.
- InChI
- InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
- InChIKey
- FYUWIEKAVLOHSE-UHFFFAOYSA-N
- SMILES
- C(N1CCCC1=O)=C.O(C=C)C(=O)C
- LogP
- 0.370 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 10-36/37/38-67-36-11-22 | ||
| 안전지침서 | 22-24/25-36/37/39-26-16 | ||
| 유엔번호(UN No.) | UN 1987 3/PG 2 | ||
| WGK 독일 | 1 | ||
| RTECS 번호 | AH3539000 | ||
| 위험 등급 | 3 | ||
| 포장분류 | II | ||
| HS 번호 | 29349990 | ||
| 독성 | LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83 | ||
| 기존화학 물질 | KE-00043 |
비닐피로리돈/비닐 아세트산 공중합체 C화학적 특성, 용도, 생산
화학적 성질
white powder용도
Poly(1-vinylpyrrolidone-co-vinyl acetate)생산 방법
Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.일반 설명
～1:2.4 mole ratio of VP:VAPharmaceutical Applications
Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.Safety Profile
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.Safety
Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.LD50 (rat, oral): >0.63 g/kg
저장
Copovidone is stable and should be stored in a well-closed container in a cool, dry place.비 호환성
Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.Regulatory Status
Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).비닐피로리돈/비닐 아세트산 공중합체 준비 용품 및 원자재
원자재
준비 용품
비닐피로리돈/비닐 아세트산 공중합체 공급 업체
글로벌( 278)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shandong Zhishang New Material Co., Ltd. | +8617653113209 |
sales002@sdzschem.com | China | 3050 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 |
saixinkeji@aliyun.com | China | 90 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9352 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |