부틸디페닐클로로실란
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부틸디페닐클로로실란 속성
- 끓는 점
- 90 °C0.01 mm Hg(lit.)
- 밀도
- 1.057 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.568(lit.)
- 인화점
- >230 °F
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- 대부분의 유기용매에 섞인다.
- 물리적 상태
- 액체
- Specific Gravity
- 1.074
- 색상
- 투명한 무색~노란색 또는 약간 갈색
- 수용성
- 물과 반응
- 감도
- Moisture Sensitive
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 644023
- CAS 데이터베이스
- 58479-61-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 14-34-37-29-20/21/22-40 | ||
| 안전지침서 | 26-36/37/39-45-8 | ||
| 유엔번호(UN No.) | UN 2987 8/PG 2 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 10 | ||
| 위험 참고 사항 | Irritant/Corrosive | ||
| TSCA | Yes | ||
| 위험 등급 | 8 | ||
| 포장분류 | II | ||
| HS 번호 | 29310095 |
부틸디페닐클로로실란 C화학적 특성, 용도, 생산
화학적 성질
Tert-Butylchlorodiphenylsilane is a colorless to pale brown oily liquid with pungent odor, may be used as silylating agent for derivatization of alcohols, ketones, carboxylic acids, amines, amides and mercaptanes selectively into functional groups in different sterical environments.물리적 성질
colorless liquid, bp 93–95°C/0.015 mmHg; n20 D 1.5680; d 1.057 g cm?3.용도
Several newmethods have been developed for using the reagent to protect primary and secondary alcohols as their TBDPS ethers. In the presence of ammonium nitrate or ammonium perchlorate, reaction between TBDPS-Cl and a primary alcohol, such as benzyl alcohol, in DMF provided excellent yields of the corresponding silyl ethers in just 15 min (eq 1).19 When silver nitrate was used as promoter, the reactions gave inferior yields under otherwise identical conditions.
When TBDPS-Cl is used to react with hemiacetals, it converts hemiacetals into ring-opened silyl ether carbonyl compounds, instead of mixed acetals.Presumably, the sizable TBDPS group presents too much steric hindrance for the formation of the corresponding mixed silyl acetals.
제조 방법
a dry 1 L, three-necked round bottomed flask is equipped with a magnetic stirring bar, a 500mL equalizing dropping funnel fitted with a rubber septum, a reflux condenser, and nitrogen inlet tube. The flask is flushed with nitrogen, then charged with 127 g (0.5 mol) of diphenyldichlorosilane in 300mL of redistilled pentane. A solution of tbutyllithium in pentane (500 mL, 0.55 mol), is transferred under nitrogen pressure to the dropping funnel using a stainless steel, double-tip transfer needle. This solution is slowly added to the contents of the flask and when the addition is complete, the mixture is refluxed 30 h under nitrogen with stirring. The suspension is allowed to cool to rt, the precipitated lithium chloride is rapidly filtered through a pad of Celite, and the latter is washed with 200mL of pentane. The solvent is removed by evaporation, and the colorless residue is distilled through a short (10 cm), Vigreux column, to give 125–132 g of the colorless title compound.Purification Methods
Purify it by repeated fractional distillaton. It is soluble in DMF and pentane [Hanessian & Lavalee Can J Chem 53 2975 1975, Robl et al. J Med Chem 34 2804 1991]. [Beilstein 4 IV 4076 for tert-butylchlorodimethylsilane.]부틸디페닐클로로실란 준비 용품 및 원자재
원자재
준비 용품
Fluvastatin sodium salt
3-AMINO-2,2-DIMETHYL-4-OXO-AZETIDINE-1-SULFONIC ACID
2-(t-Butyldiphenylsilanyloxy)Ethanol
(S)-4-BOC-MORPHOLINE-3-CARBOXYLIC ACID
4-Pentylcyclohexanone
Benzene, 1,1'-[(2-bromoethoxy)(1,1-dimethylethyl)silylene]bis-
(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(TERT-BUTYLDIPHENYLSILYLOXY)PROPANOIC ACID
(But-3-en-1-yloxy)(tert-butyl)diphenylsilane
Benzene, 1,1'-[(1,1-dimethylethyl)(2-propen-1-yloxy)silylene]bis-
2-(2-((tert-butyldiphenylsilyl)oxy)ethoxy)ethanol(WXPC0004)
6-O-(TERT-BUTYLDIPHENYLSILYL)-D-GLUCAL
METHYL-(6R)-((T-BUTYL) DIPHENYLSILYLOXY)-(2E,4E,8Z)-TETRADECATRIENOATE
2,6-DI([1-(TERT-BUTYL)-1,1-DIPHENYLSILYL]OXY)-9,10-DIHYDROANTHRACENE-9,10-DIONE
tert-Butyl(3-butynyloxy)diphenylsilane
부틸디페닐클로로실란 공급 업체
글로벌( 489)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
| Hubei Changfu Chemical Co., Ltd. | +86-027-84396550 +8617721064038 |
sales@cfsilanes.com | China | 401 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12457 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7613 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |