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염산 옥시테트라사이클린

염산 옥시테트라사이클린
염산 옥시테트라사이클린 구조식 이미지
카스 번호:
2058-46-0
한글명:
염산 옥시테트라사이클린
동의어(한글):
염산옥시테트라사이클린;염산옥시테트라사이클린(OXYTETRACYCLINEHYDROCHLORIDE)
상품명:
Oxytetracycline hydrochloride
동의어(영문):
OTC;tm5;nsc9169;mepatar;TOXINAL;otetryn;oxlopar;GEOMYCIN;Oxycycin;Oxycline
CBNumber:
CB9311671
분자식:
C22H25ClN2O9
포뮬러 무게:
496.89
MOL 파일:
2058-46-0.mol

염산 옥시테트라사이클린 속성

녹는점
180°C
알파
-188~-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis)
저장 조건
0-6°C
용해도
Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline.
물리적 상태
crystalline
색상
yellow
수소이온지수(pH)
2.0~3.0 (10g/l, 25℃)
수용성
>100 g/L
감도
Light Sensitive
최대 파장(λmax)
360nm(H2O)(lit.)
Merck
14,6976
BRN
3853107
CAS 데이터베이스
2058-46-0(CAS DataBase Reference)
EPA
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5, 5a,6,11,12a-octahydro-3,5, 6,10,12,12a-hexahydroxy-6- methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6S,12aS)-(2058-46-0)

안전

위험품 표기 Xn,Xi
위험 카페고리 넘버 63-36-36/37/38
안전지침서 36/37/39-26-36-36/37
유엔번호(UN No.) UN 3077 9/PG III
WGK 독일 2
RTECS 번호 QI8225000
F 고인화성물질 8-10-23
TSCA Yes
위험 등급 9
포장분류 III
HS 번호 29413000

염산 옥시테트라사이클린 MSDS


Oxytetracycline hydrochloride

염산 옥시테트라사이클린 C화학적 특성, 용도, 생산

화학적 성질

Yellow Crystalline Solid

용도

Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial

용도

Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

상표명

Terramycin (Pfizer).

일반 설명

Early in 1950, Finlay et al.182 reported the isolation of oxytetracycline(Terramycin) from S. rimosus. This compoundwas soon identified as a chemical analog of chlortetracycline that showed similar antibiotic properties. The structureof oxytetracycline was elucidated by Hochstein et al.183 andthis work provided the basis for the confirmation of thestructure of the other tetracyclines.
Oxytetracycline hydrochloride is a pale yellow, bitter,crystalline compound. The amphoteric base is only slightlysoluble in water and slightly soluble in alcohol. It is odorlessand stable in air but darkens on exposure to strong sunlight.The hydrochloride salt is a stable yellow powder that ismore bitter than the free base. It is much more soluble inwater, 1 g dissolving in 2 mL, and more soluble in alcoholthan the free base. Both compounds are inactivated rapidlyby alkali hydroxides and by acid solutions below pH 2. Bothforms of oxytetracycline are absorbed rapidly and equallywell from the digestive tract, so the only real advantage thefree base offers over the hydrochloride salt is that it is lessbitter. Oxytetracycline hydrochloride is also used for parenteraladministration (intravenously and intramuscularly).

일반 설명

Odorless fluffy yellow solid or yellow powder. Bitter taste.

공기와 물의 반응

Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.

반응 프로필

Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.

화재위험

Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.

염산 옥시테트라사이클린 준비 용품 및 원자재

원자재

준비 용품


염산 옥시테트라사이클린 공급 업체

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