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Bestatin

Bestatin 구조식 이미지
카스 번호:
58970-76-6
상품명:
Bestatin
동의어(영문):
nk421;BENIMEX;UBENIMEX;BESTATIN;NSC 265489;Bestatin, >=99%;Ubenimex Ubenimex;Bestatin free base;UbeniMex(Bestatin);Bestatin, UbeniMex
CBNumber:
CB9324019
분자식:
C16H24N2O4
포뮬러 무게:
308.37
MOL 파일:
58970-76-6.mol

Bestatin 속성

녹는점
245 °C (dec.)(lit.)
알파
D20 -15.5° (c = 1.0 in 1N HCl)
끓는 점
448.76°C (rough estimate)
밀도
1.0917 (rough estimate)
굴절률
1.5800 (estimate)
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
물리적 상태
Powder
산도 계수 (pKa)
8.1, 3.1(at 25℃)
색상
White
optical activity
[α]20/D 11°, c = 1 in 1 M NaOH
수용성
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.
Merck
13,9910
InChIKey
VGGGPCQERPFHOB-RDBSUJKOSA-N
CAS 데이터베이스
58970-76-6(CAS DataBase Reference)

안전

안전지침서 22-24/25
WGK 독일 3
RTECS 번호 OH2915000
HS 번호 29242998
독성 LD50 in male, female mice, male, female rats (g/kg): 1.3, 1.9, 1.9, 2.1 s.c.; 0.19, 0.19, 0.90, 0.78 i.p.; >4.0, >4.0, >2.0, >2.0 orally (Sakakibara)

Bestatin MSDS


Ubenimex

Bestatin C화학적 특성, 용도, 생산

개요

Ubenimex is an immunostimulant useful in the treatment of non-lymphocytic leukemia. In other types of cancers ubenimex added to radiotherapy or chemotherapy following surgery significantly inmases survival time through immunopotentiation.

개요

Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli. It inhibits aminopeptidase B (IC50 = 0.05 μg/ml), aminopeptidase N (IC50 = 16.9 μM), leucine aminopeptidase (IC50 = 0.01 μg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM). It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin. Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 μM. It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells. Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.

화학적 성질

white powder

Originator

Inst. of Microbial Chem (Japan)

용도

Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of all the cell lines except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were highly sensitive, with 50% growth inhibitory concentration

용도

Bestatin is "pseudo"-dipeptide isolated from Strepotmyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits good antitumour activity and is has been investigated in clinical trials.

용도

Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials.

상표명

Bestatin

생물학적 활성

Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation.

Safety Profile

Poison by intraperitoneal route.Moderately toxic by subcutaneous route. Experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.

Bestatin 준비 용품 및 원자재

원자재

준비 용품


Bestatin 공급 업체

글로벌( 335)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Chengdu Aslee Biopharmaceuticals, Inc.
+86 28 85305008
may.yang@asleechem.com CHINA 964 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58

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