세파클로르
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세파클로르 속성
- 끓는 점
- 713.4±60.0 °C(Predicted)
- 밀도
- 1.3575 (rough estimate)
- 굴절률
- 1.6100 (estimate)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 용해도
- 1M HCl: 50mg/mL, 투명하거나 매우 희미하게 탁함, 노란색
- 산도 계수 (pKa)
- pKa 1.5±0.2(H2O) (Uncertain)
- 물리적 상태
- 가루
- 색상
- 투명
- 수용성
- 10g/L(온도는 명시되지 않음)
- BRN
- 8176092
- BCS Class
- 3
- InChI
- InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
- InChIKey
- QYIYFLOTGYLRGG-GPCCPHFNSA-N
- SMILES
- N12[C@@]([H])([C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)SCC(Cl)=C2C(O)=O
- CAS 데이터베이스
- 53994-73-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
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위험 카페고리 넘버 | 42/43 | ||
안전지침서 | 22-36/37-45 | ||
WGK 독일 | 2 | ||
RTECS 번호 | XI0363000 | ||
HS 번호 | 29349990 | ||
독성 | TDLo orl-cld: 131 mg/kg/7D-I:MSK,SKN CMAJAX 126,1032,82 | ||
기존화학 물질 | KE-01537 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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세파클로르 C화학적 특성, 용도, 생산
개요
Cefaclor differs from cephalexin primarily in the bio-isosteric replacement of methyl by chlorine at C-3 and is quite acid stable, allowing oral administration. It also is quite stable to metabolism. It is less active against Gram-negative bacteria compared with the other second-generation cephalosporins but is more active against Gram-negative bacteria compared with the first-generation drugs.화학적 성질
white crystalline solid용도
Cefaclor belongs to the family of antibiotics known as the cephalosporins (cefalosporins). The cephalosporins are broad-spectrum antibiotics that are used for the treatment of septicaemia, pneumonia, meningitis, biliary-tract infections, peritonitis, and정의
ChEBI: A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.Antimicrobial activity
It is less resistant than other group 2 cephalosporins to staphylococcal β-lactamase. It is active against N. gonorrhoeae and H. influenzae and against most enterobacteria, but it is susceptible to common enterobacterial β-lactamases. Pr. vulgaris and Providencia, Acinetobacter and Serratia spp. are resistant. B. fragilis and clostridia are resistant but other anaerobes are commonly susceptible.Clinical Use
Cefaclor (Ceclor) is an orally active semisyntheticcephalosporin that was introduced in the American market in1979. It differs structurally from cephalexin in that the 3-methyl group has been replaced by a chlorine atom. It issynthesized from the corresponding 3-methylenecepham sulfoxideester by ozonolysis, followed by halogenation of theresulting β-ketoester. The 3-methylenecepham sulfoxideesters are prepared by rearrangement of the corresponding 6-acylaminopenicillanic acid derivative. Cefaclor is moderatelystable in acid and achieves enough oral absorption to provideeffective plasma levels (equal to about two-thirds of thoseobtained with cephalexin). The compound is apparentlyunstable in solution, since about 50% of its antimicrobial activityis lost in 2 hours in serum at 37°C. The antibacterialspectrum of activity is similar to that of cephalexin, but it isclaimed to be more potent against some species sensitiveto both agents. Currently, the drug is recommended for thetreatment of non–life-threatening infections caused by H.influenzae, particularly strains resistant to ampicillin.부작용
Apart from mild gastrointestinal disturbance, the drug is well tolerated. Transiently increased transaminase levels and symptomatic vaginal candidosis have been noted. Clusters of a serum sickness-like illness have been described in children.Safety Profile
Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: joints, dermatitis, increased body temperature. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí, SOx, an세파클로르 준비 용품 및 원자재
원자재
준비 용품
세파클로르 공급 업체
글로벌( 372)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shenzhen Excellent Biomedical Technology Co.,Ltd. | +86-0755-26050679 +86-15915472436 |
sale@ex-biotech.cn | China | 1031 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 |
ada@ipurechemical.com | CHINA | 3465 | 58 |
Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 |
admin@zhanyaobio.com | China | 2136 | 58 |
세파클로르 관련 검색:
아세트아미노펜 아세틸 보조 효소 A 아세틸 염화물 세파렉신 2,4-펜탄디온 클로로디플루오르메탄 페닐초산 클로로(2-)에틸에틸슐파이드 산소, 냉각된 액체 세파클로르
CEFACLOR,MONOHYDRATE,USP,CEFACLOR HYDRATE,CEFACLOR MONOHYDRATE
Cefixime
PHENYL VALERATE
Cefadroxil
Cefalexin Extend-release Tablet
2-CHLOROETHYL METHYL SULFIDE
7-Amino-3-cephem-4-carboxylic acid
Cefaclor Dispensible Tablet