Loteprednol etabonate
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Loteprednol etabonate 속성
- 녹는점
- 220.5-223.5
- 끓는 점
- 600.1±55.0 °C(Predicted)
- 밀도
- 1.31±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO: 용해성5mg/mL, 투명(가온)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 14.06±0.70(Predicted)
- 색상
- 흰색에서 베이지색
- 수용성
- <1mg/L(23℃)
- 안정성
- 흡습성
- InChIKey
- DMKSVUSAATWOCU-ICASLIHPSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| HS 번호 | 2937.22.0000 |
Loteprednol etabonate C화학적 특성, 용도, 생산
개요
Loteprednol etabonate was introduced in the US as Lotemax (opththalmic suspension at 0.5%) for the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the ocular globe, and as Alrex (opththalmic suspension at 0.2%) for the symptomatic treatment of seasonal allergic conjunctivitis. Loteprednol etabonate is a novel soft corticosteroid with a superior efficacy and an improved safety profile compared to prior ophthalmic steroids due to its metabolic lability and a fast enzymatic transformation to inactive metabolite. A combination of Lotemax with the antibiotic Tobramycin is currently under development.화학적 성질
x용도
Biological Activity Chemical Information Tech Support & FAQs Biological Activity Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology. It is used for the treatment of steroid responsive inflammatory conditions of the eye su일반 설명
Loteprednol etabonate,chloromethyl 17α-[(ethoxycarbonyl)oxy]-11β-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate (Alrex,Lotemax), has a modified carboxylate at the C17 positionrather than the typical ketone functionality. This modificationmaintains affinity for the GR but allows facile metabolismto inactive metabolites. This limits the systemic actionof the drug. Loteprednol etabonate is used as anophthalmic suspension that has greatly reduced systemicaction because of rapid metabolism to the inactive carboxylate.Loteprednol etabonate 준비 용품 및 원자재
원자재
히드로코르티손
수산화나트륨
나트륨 과요오드산
클로로포름산에틸
(11beta,17alpha)-11,17-dihydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid
프레드니솔원
준비 용품
Loteprednol etabonate 공급 업체
글로벌( 349)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
| Jinan Chenghui-Shuangda Chemical Co.,Ltd | +86-531-58897082 |
ericqiao@jnchsd.com | CHINA | 158 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 |
info@pharmachemm.com | China | 246 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 |
christine@shengqipharm.com | CHINA | 491 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Loteprednol etabonate 관련 검색:
다이메틸 설폭사이드 다이메틸 프탈레이트 N,N-다이메틸폼아마이드 황화디메틸 다이메틸 푸마르산 에탄 디메틸 에테르
Pranoprofen
GR (Glucocorticoid receptor)
Glucocorticoid receptor agonist
CHLOROPHOSPHONAZO III
Loteprednol
Loteprednol Etabonate-d5
loteprednol Impurity 8
Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, (11β,17α)-
loteprednol Impurity 7
LOTEPREDNOL ETABONATE-D3
Loteprednol etabonate