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칼슘 인산염, 디베이직, 이염화물

칼슘 인산염, 디베이직, 이염화물
칼슘 인산염, 디베이직, 이염화물 구조식 이미지
카스 번호:
7789-77-7
한글명:
칼슘 인산염, 디베이직, 이염화물
동의어(한글):
디칼슘인산염이염화물CALCIUMMONOHYDROGENPHOSPHATEDIHYDRATE;브루쉬트;칼슘인산염,디베이직,이염화물;칼슘인산염이염화물;칼슘인산염,디베이직,이염화물(CALCIUMPHOSPHATE,DIBASIC,DIHYDRATE);다이칼슘포스페이트다이하이드레이트
상품명:
DICALCIUM PHOSPHATE DIHYDRATE
동의어(영문):
DiTab;Di-tab;Bekapress D 2;CALCIUM PHOSPH;DICALCIUM PHOSPHAT;BicalciuM phosphate;dicalciurn phosphate;Calcium phosphate di;calcium phosphate,secondary;Calciumhydrogenphosphate,dih
CBNumber:
CB9439551
분자식:
CaH5O6P
포뮬러 무게:
172.09
MOL 파일:
7789-77-7.mol

칼슘 인산염, 디베이직, 이염화물 속성

녹는점
109°C -H₂O
밀도
2.31
용해도
Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.
물리적 상태
Solid
색상
White to almost white
수용성
Slightly soluble in water. Soluble in dilute hydrochloric, nitric, and acetic acid. Insoluble in alcohol
안정성
Stable. Incompatible with acids.
InChIKey
XAAHAAMILDNBPS-UHFFFAOYSA-L
CAS 데이터베이스
7789-77-7(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 1
TSCA Yes
HS 번호 28352590
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

칼슘 인산염, 디베이직, 이염화물 MSDS


Calcium hydrogenphosphate dihydrate

칼슘 인산염, 디베이직, 이염화물 C화학적 특성, 용도, 생산

화학적 성질

white crystalline solid

화학적 성질

Dibasic calcium phosphate dihydrate is a white, odorless, tasteless powder or crystalline solid. It occurs as monoclinic crystals.

용도

Replenisher (calcium); pharmaceutic aid (tablet base).

용도

Dicalcium Phosphate, Dihydrate is a source of calcium and phosphorus that also functions as a dough conditioner and bleaching agent. It functions as a dough conditioner in bakery products, as a bleaching agent in flour, as a source of calcium and phosphorus in cereal products, and as a source of calcium for alginate gels. It contains approximately 23% calcium. It is practically insoluble in water. It is also termed dibasic calcium phosphate, dihydrate and calcium phosphate dibasic, hydrous. It is used in dessert gels, baked goods, cereals, and breakfast cereals.

용도

Dicalcium phosphate dihydrate is only slightly soluble at ordinary temperatures of mixing and holding doughs and batters. As a result, it does not release acidity for reaction with soda until late in the baking stage, when the temperature reaches 135 to 140°F. Since DCP·2H20 does not begin to react below 135°F, and the interior structure of a baked product begins to firm at about 160°F, a product that bakes rapidly may not provide sufficient time for complete release of all the C02. DCP·2H2 0, therefore, cannot be used in biscuits, pancakes or any baked product that is completely baked in less than 20 min.
Dicalcium phosphate dihydrate is seldom used by itself in leavening systems but is usually combined with fasterreacting acidic phosphates. Its major applications are in cake mixes, frozen bread doughs, and other products requiring a half hour or more to complete baking. It has a low neutralizing value, and therefore more DCP·2H20 is required to neutralize a given amount of soda than for other phosphate-leavening acids.

생산 방법

Calcium phosphates are usually manufactured by reacting very pure phosphoric acid with calcium hydroxide, Ca(OH)2 obtained from limestone, in stoichiometric ratio in aqueous suspension followed by drying at a temperature that will allow the correct hydration state to be achieved. After drying, the coarse-grade material is obtained by means of a classification unit; the fine particle-size material is obtained by milling.

상표명

CalStar (FMC); D.C.P. (Parke-Davis).

Pharmaceutical Applications

Dibasic calcium phosphate dihydrate is widely used in tablet formulations both as an excipient and as a source of calcium and phosphorus in nutritional supplements. It is one of the more widely used materials, particularly in the nutritional/health food sectors. It is also used in pharmaceutical products because of its compaction properties, and the good flow properties of the coarsegrade material. The predominant deformation mechanism of dibasic calcium phosphate coarse-grade is brittle fracture and this reduces the strain-rate sensitivity of the material, thus allowing easier transition from the laboratory to production scale. However, dibasic calcium phosphate dihydrate is abrasive and a lubricant is required for tableting, for example about 1% w/w of magnesium stearate or about 1% w/w of sodium stearyl fumarate is commonly used.
Two main particle-size grades of dibasic calcium phosphate dihydrate are used in the pharmaceutical industry. The milled material is typically used in wet-granulated, roller-compacted or slugged formulations. The ‘unmilled’ or coarse-grade material is typically used in direct-compression formulations.
Dibasic calcium phosphate dihydrate is nonhygroscopic and stable at room temperature. However, under certain conditions of temperature and humidity, it can lose water of crystallization below 1008℃. This has implications for certain types of packaging and aqueous film coating since the loss of water of crystallization appears to be initiated by high humidity and by implication high moisture vapor concentrations in the vicinity of the dibasic calcium phosphate dihydrate particles.
Dibasic calcium phosphate dihydrate is also used in toothpaste and dentifrice formulations for its abrasive properties.

Safety

Dibasic calcium phosphate dihydrate is widely used in oral pharmaceutical products, food products, and toothpastes, and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may cause abdominal discomfort.

저장

Dibasic calcium phosphate dihydrate is a nonhygroscopic, relatively stable material. However, under certain conditions the dihydrate can lose water of crystallization. This has implications for both storage of the bulk material and coating and packaging of tablets containing dibasic calcium phosphate dihydrate.
The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise it from a near-saturated solution in 50% aqueous reagent grade phosphoric acid at 100o by filtering through fritted glass and cooling to room temperature. The crystals are filtered off, and this process is repeated three times using fresh acid. For the final crystallisation the solution is cooled slowly with constant stirring to give thin plate crystals that are filtered off on a fritted glass funnel, washed free of acid with anhydrous acetone and dry in a vacuum desiccator [Egan et al.J Am Chem Soc 78 1811 1956].

비 호환성

Dibasic calcium phosphate dihydrate should not be used to formulate tetracycline antibiotics. Dibasic calcium phosphate dihydrate has been reported to be incompatible with indomethacin, aspirin, aspartame, ampicillin, cephalexin, and erythromycin. The surface of dibasic calcium phosphate dihydrate is alkaline and consequently it should not be used with drugs that are sensitive to alkaline pH.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

칼슘 인산염, 디베이직, 이염화물 준비 용품 및 원자재

원자재

준비 용품


칼슘 인산염, 디베이직, 이염화물 공급 업체

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