Anti-TAP antibody, Mouse monoclonal C화학적 특성, 용도, 생산
용도
Anti-TAP antibody, mouse monoclonal may be used in:
enzyme linked immunosorbent assay (ELISA)
immunoblotting
immunoprecipitation
immunocytochemistry
일반 설명
TIP-associated protein (TAP), also known as nuclear export factor (NXF1), is encoded by the gene mapped to human chromosome 11q12.3. The encoded protein is a member of multigene family of evolutionarily conserved proteins. TAP contains non-canonical RNP-type RNA binding domain, four leucine-rich repeats and an NTF2-like domain. It also contains an ubiquitin-associated domain involved in the interaction with nucleoporins.
Biochem/physiol Actions
TIP-associated protein (TAP) plays an important role in carrying mRNAs from the nucleus. Elevated expression of TAP or of SRp20, enhance the production of gammaretroviral Gag polyprotein. The encoded protein might facilitate the repression of two mutations caused by insertions of endogenous retroviruses into introns of cellular genes by regulating their mature transcript levels ～2 fold.
