Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal
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Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal 속성
- 저장 조건
- -20°C
- 물리적 상태
- 완충 수용액
안전
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal C화학적 특성, 용도, 생산
용도
Mouse Monoclonal Anti-alpha-Actinin (Sarcomeric) antibody has been used for immunocytochemical (1:800) and immunohistochemical (1:100) applications.일반 설명
α-Actinin is a 100kDa actin-binding protein that is found in muscle as well as non-muscle cells. In smooth muscles, α-actinin is present in dense bodies and plaques whereas in normal skeletal muscles, it is associated with z-discs that define muscle sarcomeres. The gene encoding α-actinin is mapped to the human chromosome 11q13.2. α-Actinin belongs to the spectrin protein superfamily.α-Actinin dimerizes in an antiparallel fashion via interaction of the central rod domains. Four isoforms are found in human and mice. α-actinin-1 is ubiquitously expressed and located primarily in focal adhesions, whereas α-actinin-4 is present in certain membrane ruffles and seems to play a role in endocytosis and tumor cell motility.
ACTN1 (α-actinin-1) and ACTN4 (α-actinin-4) encodes non-muscle proteins, while ACTN2 (α-actinin-2) and ACTN3 (α-actinin-3) encodes muscle proteins.
Monoclonal Anti-α-Actinin (Sarcomeric) shows wide reactivity, as it binds to human, bovine, pig, sheep, rabbit, goat, hamster, cat, rat, mouse, dog, chicken, lizard, snake, frog and fish α-actinin.
Biochem/physiol Actions
α-Actinin maintains the structure of cytoskeletal organization and regulates muscle contraction. α-Actinin functions as an actin crosslinker and promotes cell migration. Mutations in the α-actinin gene is observed in heterogeneous hypertrophic cardiomyopathy and in juvenile onset atrial fibrillation.Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal 준비 용품 및 원자재
원자재
준비 용품
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal 공급 업체
글로벌( 1)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |