POMALIDOMIDE-PEG2-ALKYNE

POMALIDOMIDE-PEG2-ALKYNE 구조식 이미지
카스 번호:
상품명:
POMALIDOMIDE-PEG2-ALKYNE
동의어(영문):
POMALIDOMIDE-PEG2-ALKYNE
CBNumber:
CB94744213
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

POMALIDOMIDE-PEG2-ALKYNE 속성

저장 조건
2-8°C
물리적 상태
분말 또는 결정

안전

POMALIDOMIDE-PEG2-ALKYNE C화학적 특성, 용도, 생산

용도

Protein degrader builiding block Pomalidomide-PEG2-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG2-ALKYNE 준비 용품 및 원자재

원자재

준비 용품


POMALIDOMIDE-PEG2-ALKYNE 공급 업체

글로벌( 3)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068
1924344760@qq.com China 4926 58

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