Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem 속성
녹는점
215 °C (decomp)(Solv: ethyl ether (60-29-7))
끓는 점
679.4±50.0 °C(Predicted)
밀도
1.544±0.06 g/cm3(Predicted)
산도 계수 (pKa)
9.29±0.40(Predicted)
안전
Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC50 = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC50 = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC50 = 4.2 and ≥0.5 μM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme′s ATP-binding site.
Biochem/physiol Actions
Cell permeable: yes
Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem 공급 업체
