CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable, bioavailable propenone compound that specifically targets TNF receptor-associated factor 6 (TRAF6; Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40. A six-week treatment of C57BL/6 mice fed high fat diet (HFD) with this compound show significant improvement in insulin sensitivity and hepatosteatosis without affecting HFD-induced weight gain. Also reported to reduce gonadal adipose tissue inflammation and diminish the number of CD11b+F4/80+CD11c+ M1 macrophages. Inhibits NF-κB activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (IC50 15.9 μM) and reduce IL-1β and IL-6 expression in anti-CD40 antibody FGK45-stimulated primary bone marrow-derived macrophages.
Biochem/physiol Actions
Cell permeable: yes
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem 공급 업체
