InSolution H-89, Dihydrochloride - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (K
i = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (K
i = 28.3 μM), Ca
2+/calmodulin-dependent protein kinase II (K
i = 29.7 μM), protein kinase C (K
i = 31.7 μM), casein kinase I (K
i = 38.3 μM), and Rho Kinase II (IC
50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 μM) by blocking the action of Rho kinase II.
Biochem/physiol Actions
Target Ki: 48 nM against protein kinase A
InSolution H-89, Dihydrochloride - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
