Ergonovine is a water-soluble lysergic acidderivative that occurs in ergot. It is used as anoxytocic agent. Its maleate derivative is usedin the treatment of postpartum hemorrhage.
정의
ChEBI: A monocarboxylic acid amide that is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on th
uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vesse
s in the uterine wall are compressed and blood flow reduced.
위험도
Extremely toxic; vaso-constrictor; central nervous system stimulant; adrenergic blocking
compound.
건강위험
The toxicity of ergonovine is low to moderate.The toxic symptoms include excitability,respiratory depression, cyanosis, and convulsions.The intravenous LD50 value in mice is144 mg/kg.
