Leptomycin B
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Leptomycin B 속성
- 녹는점
- 41-44°, with prior softening (Hokanson)
- 알파
- D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform)
- 끓는 점
- 725.8±60.0 °C(Predicted)
- 밀도
- 1.072±0.06 g/cm3(Predicted)
- 인화점
- 11°(52°F)
- 저장 조건
- −20°C
- 용해도
- 에탄올(1 mg/ml) 용액으로 제공됩니다. 에탄올이나 DMSO를 사용하여 추가로 희석할 수 있습니다.
- 물리적 상태
- 액체
- 산도 계수 (pKa)
- 5.10±0.33(Predicted)
- 색상
- 흰색에서 황백색까지
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 용액이나 희석은 안정적이지 않습니다. 용액은 신선하게 만들어져 영업일 기준 1일 이내에 사용해야 합니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 23/25-36/38-39/23/24/25-23/24/25-11 | ||
| 안전지침서 | 7-16-24-33-45-36/37 | ||
| 유엔번호(UN No.) | UN 1230 3/PG 2 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | 3 | ||
| HS 번호 | 29419090 |
Leptomycin B C화학적 특성, 용도, 생산
용도
Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal and antibacterial and potent antitumour activities.정의
ChEBI: A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.일반 설명
Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.생물학적 활성
Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .Mechanism of action
The nuclear export inhibition mechanism involves the direct binding of Leptomycin B to exportin1, which blocks the binding of exportin1 to proteins containing the leucine-rich NES. Later, NES-exportin1 interaction was identified on a conserved region near cysteine-529 residue of human exportin1. This cysteine-529 residue on exportin1 provides LMB sensitivity because unsaturated γ-lactone in LMB undergoes a Michael-type reaction by the sulfhydryl group on cysteine residue. Once LMB is bound to exportin1, the NES-bearing nuclear export cargo fails to bind the receptor.Leptomycin B 준비 용품 및 원자재
원자재
준비 용품
Leptomycin B 공급 업체
글로벌( 130)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Minbiotech Co., Ltd. | +8617315815539 |
sales@minbiotech.com | CHINA | 129 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 |
1057@dideu.com | China | 3586 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 |
wendy@huidabiotech.com | CHINA | 87 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9358 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |