요산

요산
요산 구조식 이미지
카스 번호:
69-93-2
한글명:
요산
동의어(한글):
우르산;요산;우릭애씨드
상품명:
Uric acid
동의어(영문):
7,9-Dihydro-1H-purine-2,6,8(3H)-trione;TRIKETOPURINE;2,6,8-TRIHYDROXYPURINE;Uric aci;NSC 3975;URIC ACID;URIC OXIDE;UricAcidGr;LITHIC ACID;URIC ACID(RG)
CBNumber:
CB9681462
분자식:
C5H4N4O3
포뮬러 무게:
168.11
MOL 파일:
69-93-2.mol
MSDS 파일:
SDS

요산 속성

녹는점
>300 °C (lit.)
끓는 점
297.02°C (rough estimate)
밀도
1,9 g/cm3
굴절률
1.9900 (estimate)
저장 조건
Sealed in dry,2-8°C
용해도
수성 베이스(약간 용해됨, 가열됨)
물리적 상태
수정 같은
산도 계수 (pKa)
3.89(at 12℃)
색상
흰색에서 황백색까지
냄새
냄새 없는
수용성
1M 수산화나트륨 용액에 용해됩니다. 물에 약간 용해됩니다. 에테르와 알코올에 불용성.
Merck
14,9875
BRN
156158
안정성
안정적인. 산, 염기, 산화제와 호환되지 않습니다.
LogP
-1.730 (est)
CAS 데이터베이스
69-93-2(CAS DataBase Reference)
EPA
Uric acid (69-93-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 33-36/37/38
안전지침서 24/25-36-26
WGK 독일 3
RTECS 번호 YU7050080
TSCA Yes
HS 번호 29339900
독성 A nitrogenous end product and the principal excretory product of purine metabolism in mammals. In birds and reptiles, it is the principal end product of nitrogen metabolism in general. Defects in uric acid metabolism and excretion appear to be associated with a number of disease states, and it frequently occurs as a component of renal calculi. It has not been associated closely with toxic insults except in the case of lead poisoning. Lead causes an elevation in blood uric acid concentration (uric acidemia) and a decrease in uric acid excretion.
기존화학 물질 KE-10742
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 GHS hazard pictograms P261, P271, P304+P340, P312
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
1 0

요산 C화학적 특성, 용도, 생산

화학적 성질

Uric acid (C5H4O3N4) is a white solid that is insoluble in cold water, alcohol, or ether and sparingly soluble in hot water. It acts as a weak dibasic acid, creating two series of salts, with most being very slightly soluble in water (except for lithium urate, which is soluble).

출처

Uric acid is found in the urine, blood, and muscle juices of carnivorous animals (herbivorous animals secrete hippuric acid), in the excrement of birds, serpents and insects, and is an oxidation product of the complex nitrogenous compounds of the animal organism.

용도

Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.

정의

A nitrogen compound produced from purines. In certain animals (e.g. birds and reptiles), it is the main excretory product resulting from breakdown of amino acids. In humans, uric acid crystals in the joints are the cause of gout.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise uric acid from hot distilled H2O (the solubility in H2O is 1part/39,000parts at 18o and 1part/2,000parts at 100o). It is best purified by dissolving in an alkaline solution and acidifying with dilute HCl and drying it at 100o in a vacuum. [Bergmann & Dikstein J Am Chem Soc 77 691 1955, Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp256-257 1971, ISBN 0-471-38205-1, Beilstein 26 H 513, 26 I 151, 26 II 293, 26 III/IV 2619.]

참고 문헌

Regulation of uric acid metabolism and excretion DOI:10.1002/RECL.19881071209
Purification of Laboratory Chemicals, Fourth Edition. By W. L. F. DOI:10.1002/RECL.19881071209
Van Nostrand’s Scientific Encyclopedia DOI:10.1007/978-1-4757-6918-0
The Facts on File Dictionary of Chemistry DOI:10.5860/choice.37-4227
A Dictionary of Chemistry (6th edition) DOI:10.1108/09504120910935291
Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis DOI:10.3390/ijms222212394

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