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덱사메타손 아세트산, 무수물

덱사메타손 아세트산, 무수물
덱사메타손 아세트산, 무수물 구조식 이미지
카스 번호:
1177-87-3
한글명:
덱사메타손 아세트산, 무수물
동의어(한글):
덱사메타손아세트산,무수물;덱사메타손아세트산,무수물(DEXAMETHASONEACETATE,ANHYDROUS)
상품명:
Dexamethasone-17-acetate
동의어(영문):
Dectan;Panasone;Dectancyl;NSC 39471;Decadronal;Decadron-la;Fortecortin;Dexacortisyl;Decadron-L.A.;Dalalone L.A.
CBNumber:
CB9703269
분자식:
C24H31FO6
포뮬러 무게:
434.5
MOL 파일:
1177-87-3.mol

덱사메타손 아세트산, 무수물 속성

녹는점
238-240 °C(lit.)
알파
D25 +73° (chloroform) (Arth, 1958); D +77.6° (Oliveto)
끓는 점
579.4±50.0 °C(Predicted)
밀도
1.1517 (estimate)
굴절률
87 ° (C=1, Dioxane)
저장 조건
2-8°C
용해도
Soluble at 100 mg/ml in acetone
물리적 상태
Powder
산도 계수 (pKa)
12.08±0.70(Predicted)
색상
White
수용성
13mg/L(25 ºC)
Merck
2943
BRN
2342608
CAS 데이터베이스
1177-87-3(CAS DataBase Reference)
NIST
Prednisolone, 9alpha-fluoro-16alpha-methyl-, acetate(1177-87-3)
EPA
Dexamethasone-21-acetate (1177-87-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 43
안전지침서 36/37
WGK 독일 3
RTECS 번호 TU4050000
TSCA Yes
HS 번호 29372290
기존화학 물질 KE-00140
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P321 (…) 처치를 하시오.
P333+P313 피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.

덱사메타손 아세트산, 무수물 C화학적 특성, 용도, 생산

화학적 성질

Off-White Solid

Originator

Dexacen,Central,US,1977

용도

Dexamethasone has many uses in the treatment of cancer. Dexamethasone relieves inflammation in various parts of the body. To treat or prevent allergic reactions. As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions. As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma. It is also used for replacement therapy in adrenal insufficiency and in a screening test for the diagnosis of cushing's syndrome. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.

용도

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

Manufacturing Process

The preparation of dexamethasone acetate is described in US Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-?1,4-pregnadiene-3,20-dione (prepared according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The steroid dissolves in about 15 minutes. The reaction mixture is shaken for two hours at a temperature between 0 and +5°C, and then poured into 75 cc of
water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture is vacuum filtered, the filter cake washed and then dried at 100°C, yielding 460 mg of crude hexadecadrol contaminated with a small amount of the starting material. A single recrystallization from methylene chloride yields 370 mg of the pure product having a melting point of 170°C and 229°C. The mother liquor yields 62 mg of the starting material, and a remainder constituting a mixture of starting and final materials with little other contamination.

상표명

Decadron (Merck).

Therapeutic Function

9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione

Safety Profile

Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]

덱사메타손 아세트산, 무수물 준비 용품 및 원자재

원자재

준비 용품


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