8-히드록시-5-니트로퀴노린
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8-히드록시-5-니트로퀴노린 속성
- 녹는점
- 181-183 °C(lit.)
- 끓는 점
- 325.64°C (rough estimate)
- 밀도
- 1.3907 (rough estimate)
- 굴절률
- 1.5570 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 알코올: 매우 약간 용해됨
- 산도 계수 (pKa)
- 2.55±0.10(Predicted)
- 물리적 상태
- powder to crystal
- 색상
- Light yellow to Brown to Dark green
- Merck
- 14,6655
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 23/24/25-36/37/38-22/24/25-20/21/22 | ||
| 안전지침서 | 26-36-45 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | VC8225000 | ||
| 위험 참고 사항 | Toxic/Irritant | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| HS 번호 | 29334900 | ||
| 독성 | LD50 oral in rat: 510mg/kg |
8-히드록시-5-니트로퀴노린 C화학적 특성, 용도, 생산
개요
Nitroxoline is an 8-hydroxyquinoline that has diverse biological activities, including antibacterial, antiproliferative, and bromodomain interaction-inhibiting properties. Nitroxoline is active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively). It also inhibits biofilm formation of certain strains of multidrug-resistant (MDR) A. baumannii and P. aeruginosa, as well as methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE) with minimum biofilm eradication concentration (MBEC) values of 46.9, 1,500, 188, and 125 μM, respectively. Nitroxoline inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively). In vivo, it reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model when administered at a dose of 80 mg/kg per day. Nitroxoline also inhibits the interaction between the first bromodomain of bromodomain-containing protein 4 (BRD4) with acetylated histone H4 with an IC50 value of 0.98 μM.화학적 성질
ochre-yellow to brownish crystalline powder용도
antibacterial정의
ChEBI: A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.World Health Organization (WHO)
Nitroxoline, a urinary antiseptic, was introduced in the mid-1960s. By the early 1970s long-term animal studies revealed the development of cataracts in rats and, although no serious adverse effects had been reported in man, the drug was withdrawn in at least two countries. Preparations containing nitroxoline remain widely available.8-히드록시-5-니트로퀴노린 준비 용품 및 원자재
원자재
8-Quinolinol, 5-nitro-, 8-acetate
5-nitroso-8-hydroxyquinoline hydrochloride
8-ETHOXYQUINOLINE
5-NITROSO-8-HYDROXYQUINOLINE
8-Ethoxy-5-nitroquinoline
2-아미노-4-나이트로페놀
준비 용품
8-히드록시-5-니트로퀴노린 공급 업체
글로벌( 289)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10828 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 |
1047@dideu.com | China | 3408 | 58 |